Association between PON1 5'-regulatory region polymorphisms, PON1 activity and ischemic stroke.

@article{Kim2009AssociationBP,
  title={Association between PON1 5'-regulatory region polymorphisms, PON1 activity and ischemic stroke.},
  author={No Soo Kim and Byoung Kab Kang and Min Ho Cha and Se-mi Oh and Mi Mi Ko and Oksun Bang},
  journal={Clinical biochemistry},
  year={2009},
  volume={42 9},
  pages={857-63}
}
OBJECTIVES Paraoxonase I (PON1) was known as a risk factor for cerebrovascular diseases. This study assessed the association of single nucleotide polymorphisms (SNPs) in the PON1 5'-regulatory region with ischemic stroke and serum PON1 activity. DESIGN AND METHODS Study subjects consisted of 418 healthy controls and 86 ischemic stroke patients with small vessel occlusion. SNPs were identified by DNA sequencing and a primer extension-based method. RESULTS Among 10 identified SNPs, only… CONTINUE READING