Association between Major Depressive Disorder and the –1438A/G Polymorphism of the Serotonin 2A Receptor Gene

@article{Choi2004AssociationBM,
  title={Association between Major Depressive Disorder and the –1438A/G Polymorphism of the Serotonin 2A Receptor Gene},
  author={Myoung-Jin Choi and Heon-Jeong Lee and Hong-Pyo Lee and Byung-Joo Ham and Ji Hyun Cha and Seung-Ho Ryu and Min-Soo Lee},
  journal={Neuropsychobiology},
  year={2004},
  volume={49},
  pages={38 - 41}
}
This study investigated the possible effect of the –1438A/G single-nucleotide polymorphism in the promoter region of the serotonin 2A receptor (5-HTR2A) gene on major depressive disorder (MDD) in a Korean population. This polymorphism was analyzed in 189 patients with MDD and in 148 unrelated healthy controls using a case-control design, which revealed a significant difference in the genotype distributions (χ2 = 10.78, d.f. = 2, p = 0.005). The frequency of the –1438G allele was also much… 

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