Association between Major Depressive Disorder and the –1438A/G Polymorphism of the Serotonin 2A Receptor Gene

  title={Association between Major Depressive Disorder and the –1438A/G Polymorphism of the Serotonin 2A Receptor Gene},
  author={Myoung-Jin Choi and Heon-Jeong Lee and Hong-Pyo Lee and Byung-Joo Ham and Ji Hyun Cha and Seung-Ho Ryu and Min-Soo Lee},
  pages={38 - 41}
This study investigated the possible effect of the –1438A/G single-nucleotide polymorphism in the promoter region of the serotonin 2A receptor (5-HTR2A) gene on major depressive disorder (MDD) in a Korean population. This polymorphism was analyzed in 189 patients with MDD and in 148 unrelated healthy controls using a case-control design, which revealed a significant difference in the genotype distributions (χ2 = 10.78, d.f. = 2, p = 0.005). The frequency of the –1438G allele was also much… 

Tables from this paper

No relationship found between -1438A/G polymorphism of the serotonin 2A receptor gene (rs6311) and major depression susceptibility in a northeastern Thai population.

This single nucleotide polymorphism appears not to be involved in the etiology of MDD, and a possible association between rs6311 polymorphism and major depressive disorder in a northeastern Thai population is looked for.

Serotonin Receptor 2A Gene Polymorphism (–1438A/G) and Short-Term Treatment Response to Citalopram

The results suggest that the G allele of the –1438A/G polymorphism in the 5-HTR2A gene is associated with MDD, and that patients with –1437G/–1438G have a better response to citalopram treatment than patients with–1437A/– 1438A or –1434A/-1434G.

Association study between 5-HT2A and NET gene polymorphisms and recurrent major depression disorder in Chinese Han population.

5-HT2A receptor gene variants may be involved in the etiology of MDD, although the results must be verified in larger samples and different ethnicities.

Association between Serotonin 2A Receptor Gene Polymorphism and Posttraumatic Stress Disorder

It is suggested that the 5-HTR2A GG genotype is one of the possible genetic factors for susceptibility to PTSD, especially in the female population.

Meta-analysis of association between the -1438A/G (rs6311) polymorphism of the serotonin 2A receptor gene and major depressive disorder

The current meta-analysis indicated that the SNP rs6311 within the 5-HTR2A gene may be not associated with an increased risk for MDD, but further study is needed to acquire more direct evidence.

HTR2A−1438A/G polymorphism influences the risk of schizophrenia but not bipolar disorder or major depressive disorder: A meta‐analysis

It is found that the association of the HTR2A −1438A/G polymorphism with SZ depends on the ethnic origin of the study population, and this genetic variant does not modify the susceptibility to BD or MDD.

Is there a Link Between Anxiety, Depressive Disorders and 5HT 2A Receptor Gene Polymorphism? - Study from A Conflict Area,

To study 5HT-2A -1438 A/G single nucleotide polymorphism in depression and anxiety disorders in India-controlled Kashmir, patients with depression disorders, and unrelated healthy volunteers (controls) were studied in a case- control study design.

Association Study of a Serotonin Receptor 2A Gene -1438A/G Polymorphism and Anxiety-Related Traits

Findings suggest that the -1438A/G polymorphism of 5HTR2A might not be associated with anxiety sensitivity or trait anxiety.

Serotonin 1A receptor gene and major depressive disorder: an association study and meta-analysis

The results suggest that HTR1A may not have a role in the pathophysiology of Japanese MDD patients, and seven population-based association studies, including this study, met the criteria for the meta-analysis of rs6295.

Is there a Link Between Anxiety , Depressive Disorders and 5 HT 2 A Receptor Gene Polymorphism ? – Study from A Conflict Area , India-controlled Kashmir

The findings confirm the role of this locus in psychiatric disorders and further show that the association remains robust in a distressed society.



Analysis and meta-analysis of two serotonin transporter gene polymorphisms in bipolar and unipolar affective disorders.

The results suggest that the promoter allele 2, which has previously been shown to result in lower levels of serotonin transporter transcription, may be associated with affective disorder risk.

Association between depressed mood in the elderly and a 5‐HTR2A gene variant

  • M. JanssonM. Gatz N. Pedersen
  • Biology, Psychology
    American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
  • 2003
The results suggest that there might be different genetic mechanisms for males and females contributing to the development of depressed mood in the elderly, and the 5‐HT transporter gene was not associated with depression in this elderly population.

Association between seasonal affective disorder and the 5-HT2A promoter polymorphism, −1438G/A

It is shown that the −1438g/a 5-ht2A promoter variant is associated with SAD but not with seasonality, and it is suggested that the association may instead be with the depressive symptoms of SAD.

Impulsive Traits and 5-HT2A Receptor Promoter Polymorphism in Alcohol Dependents: Possible Association but No Influence of Personality Disorders

Inpatient alcohol dependents showed a significant association between 5-HT2A A alleles and impulsive traits, independent of the presence of APD or BPD, and this is the first report about an association of 5- HT2A promoter polymorphism and impulsiveness behavior in alcohol dependent.