Association between Insulin-Like Growth Factor-1 and Uric Acid in Chinese Children and Adolescents with Idiopathic Short Stature: A Cross-Sectional Study

  title={Association between Insulin-Like Growth Factor-1 and Uric Acid in Chinese Children and Adolescents with Idiopathic Short Stature: A Cross-Sectional Study},
  author={Panpan Wang and Baolan Ji and Qian Shao and Mei Zhang and B. Ban},
  journal={BioMed Research International},
Objective The aim of this study was to examine the relationship between insulin-like growth factor-1 (IGF-1) and serum uric acid (UA) in Chinese children and adolescents with idiopathic short stature (ISS). Methods A cross-sectional study of 91 Chinese children and adolescents with ISS was performed. Anthropometric measurements and biochemical parameters were tested. The standard deviation score of IGF-1 (IGF-1 SDS) was calculated. Results A univariate analysis displayed a significant positive… Expand
Relationship between hemoglobin and insulin-like growth factor-1 in children and adolescents with idiopathic short stature
It is demonstrated that Hb is associated with IGF-1 in Chinese children and adolescents with ISS, but when the concentration of Hb exceeded a certain range, with the increase of HB, IGF- 1 decreased instead. Expand
Association Between Uric Acid and Insulin-Like Growth Factor-1 in Type 2 Diabetes Mellitus
  • Fang Liu, Yaru Wang, Qiang Zhao, Mei Zhang, B. Ban
  • Medicine
  • International journal of general medicine
  • 2021
A nonlinear relationship between UA and IGF-1 in Chinese adults with T2DM was discovered after adjusting for confounding factors and when the UA levels reached the inflection point, IGF- 1 levels negatively correlated with the increase in UA. Expand
Association between serum uric acid and triglycerides in Chinese children and adolescents with short stature
The present study identified the non-linear association of SUA and TG levels with short children and adolescents, based on BMI status, and suggests that health status should be considered for short stature children with high SUA levels, especially in children with a high BMI standard deviation score. Expand
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Investigation of the levels of insulin-like growth factor-1(IGF-1), total ghrelin and insulin resistance, as well as certain micronutrients affecting children growth and skeletal maturity in nutritionally stunted Egyptian children highlighted the importance of early detection of abnormalities in growth hormone / IGF-1 axis and micronsutrients levels. Expand
Growth hormone peak modifies the effect of BMI on increased systolic blood pressure in children with short stature
It was found that SBP was significantly higher in the SGHD group than in the non-SGHD group (p = 0.045), and BMISDS is a significant factor for higher SBP in SGHD patients but not in non-sgHD patients. Expand
Maternal undernutrition during pregnancy and lactation affects testicular morphology, the stages of spermatogenic cycle, and the testicular IGF-I system in adult offspring
It is concluded that maternal undernutrition during pregnancy and lactation leads to long-lasting effects on adult male offspring testicular morphology, spermatogenesis, and IGF-I testicular system. Expand
A heterozygous point mutation of the ANKRD11 (c.2579C>T) in a Chinese patient with idiopathic short stature
Pathogenic variants of ANKRD11 have been reported to cause KBG syndrome characterized by short stature, characteristic facial appearance, intellectual disability, macrodontia, and skeletal anomalies.Expand


Association of Uric Acid with Obesity and Endothelial Dysfunction in Children and Early Adolescents
The correlation between UA and FMD showed gender differences and might be affected by the hormonal status, and the cutoff level of serum UA as a marker of the metabolic syndrome in obese children was affected by both age and gender. Expand
Nutritional Status in Short Stature Children Is Related to Both Ghrelin and Insulin-like Growth Factor I Concentrations
In short, thin children, despite elevated ghrelin production, the low IGF-I concentration is observed, probably due to undernutrition and worse IGF- I formation. Expand
Low circulating insulin-like growth factor-1 levels are associated with high serum uric acid in nondiabetic adult subjects.
An inverse relationship between IGF-1 and uric acid levels in adults is demonstrated and it is suggested that uric acids might affect hepatic IGF- 1 synthesis, which is associated with cardio-metabolic disorders. Expand
Serum uric acid is independently and linearly associated with risk of nonalcoholic fatty liver disease in obese Chinese adults
After adjustment for insulin resistance (IR), components of metabolic syndrome (MetS) and other potential confounders, elevated SUA is independently associated with increased risk of NAFLD, with the adjusted OR of 1.528–2.031 (p < 0.001). Expand
Standardized centile curves and reference intervals of serum insulin-like growth factor-I (IGF-I) levels in a normal Japanese population using the LMS method.
The present study established age- and gender-specific normative IGF-I data for the Japanese population and showed the utility of these references for screening patients with severe GHD. Expand
Association of diet with serum insulin-like growth factor I in middle-aged and elderly men.
In this population of healthy well-nourished men, greater dietary intakes of protein, zinc, red meat, and fish and seafood were associated with higher IGF-I concentrations. Expand
On the non-linear association between serum uric acid levels and all-cause mortality rate in patients with type 2 diabetes mellitus.
SUA was not linearly associated with all-cause mortality rate in patients with type 2 diabetes mellitus, providing further evidence on the J-shaped relationship between SUA levels and mortality rate. Expand
Insulin-Like Growth Factor-I is a Marker for the Nutritional State.
The effects of nutrition on the GH/IGF-I axis is summarized, and the clinical implications of these interactions throughout childhood are reviewed, both in under-nutrition and over-nutrition. Expand
Circulating Levels of Uric Acid and Risk for Metabolic Syndrome.
A significant association between hyperuricemia and metabolic syndrome in low-income young adults in Mexico showed a significant association with estimated risk of CVD in type 2 diabetic patients. Expand
Association between serum uric acid and cardiovascular mortality and all-cause mortality: a cohort study
In the current large relatively healthy population-based observational study, SUA showed no significant association with all-cause and cardiovascular mortality. Expand