Association between Insulin-Like Growth Factor-1 and Relative Skeletal Maturation: A Retrospective Cohort Study of Short Children and Adolescents

@article{Zhao2020AssociationBI,
  title={Association between Insulin-Like Growth Factor-1 and Relative Skeletal Maturation: A Retrospective Cohort Study of Short Children and Adolescents},
  author={Qianqian Zhao and Mei Zhang and Yuntian Chu and Baolan Ji and H. Pan and Hailing Sun and B. Ban},
  journal={BioMed Research International},
  year={2020},
  volume={2020}
}
Objective Delays in skeletal maturity are related to bone mass and fracture risk in children, but the factors that determine it are unknown. We aimed to identify the association between insulin-like growth factor-1 (IGF-1) and skeletal maturation before and after growth hormone (GH) treatment. Methods In this retrospective cohort study, we observed 783 short children and adolescents, 229 of whom received GH therapy. Skeletal maturation was assessed based on the difference between bone age (BA… Expand
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References

SHOWING 1-10 OF 42 REFERENCES
Factors affecting bone age maturation during 3 years of growth hormone treatment in patients with idiopathic growth hormone deficiency and idiopathic short stature
TLDR
GH treatment may increase the predicted adult height during this period because the BA progression rate was considered to be clinically acceptable, and the baseline BA-CA, IGF-1 SDS, and GH dose did not influence BA progression. Expand
Relationships of IGF-I and Androgens to Skeletal Maturation in Obese Children and Adolescents
UNLABELLED IGF-I and androgens are postulated to accelerate skeletal maturation in obese children. METHODS We studied weight status (BMI-SDS), height-SDS, IGF-I, cortisol, DHEA-S, and testosteroneExpand
Skeletal growth and bone mineral acquisition in type 1 diabetic children; abnormalities of the GH/IGF-1 axis.
TLDR
Clinical studies that address the alterations in the GH/IGF-I axis, linear growth velocity, and BMD in children and adolescents with T1DM are summarized; and the possible molecular mechanisms that may contribute to an attenuation of linear growth and to the reduction in the acquisition of peak bone mass are reviewed. Expand
Effects of Recombinant Human Growth Hormone on Height and Skeletal Maturation in Growth Hormone-Deficient Children with and without Severe Pretreatment Bone Age Delay
TLDR
RhGH has a beneficial effect on growth in prepubertal GHD children at all levels of pretreatment BA delay and predicted adult height Z-scores at pubertal onset. Expand
Growth Hormone/Insulin-Like Growth Factor-1 Axis as Related to Body Mass Index in Patients with Idiopathic Short Stature
TLDR
Iiopathic short stature patients were found to have lower IGF-1 concentrations than BMI-matched peers, a finding supporting presence of an impairment in the somatotropic axis. Expand
25-hydroxyvitamin D, insulin-like growth factor-I, and bone mineral accrual during growth.
TLDR
Prospective data in early adolescent females indicate that both 25(OH)D and IGF-I have a significant impact on bone mineral accrual; however, the positive association of IGF-i and BMC accruals is greater than the negative association of 25( OH)D. Expand
Evaluation of Safety and Efficacy of Growth Hormone Therapy by IGF-1 Z Score in Children with Short Stature
TLDR
IGF-1-based GH dosing targeted to age- and gender-adjusted means may save medical costs and offer a more dose-sparing and potentially safer mode of therapy compared with traditional weight-based dosing. Expand
Relative Skeletal Maturation and Population Ancestry in Nonobese Children and Adolescents
  • S. McCormack, A. Chesi, +12 authors B. Zemel
  • Medicine
  • Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
  • 2017
TLDR
It is concluded that advancement in relative skeletal maturation was associated with AA ancestry in healthy, non‐obese children, independent of growth, body composition, and puberty. Expand
The Use of Bone Age in Clinical Practice – Part 1
TLDR
The assessment of skeletal maturity provides an important contribution to the diagnostic workup and management of children with short stature and in chronic renal failure, the assessment of BA increases due to increased sensitivity of the growth plate to sex steroids, thus further impairing adult height. Expand
Sex steroids in relation to sexual and skeletal maturation in obese male adolescents.
TLDR
Obese boys have lower circulating SHBG and TT concentrations, but similar FT concentrations during mid and late puberty in parallel with a normal pubertal progression and serum PSA levels, indicating that in obese boys, serum FT concentration is a better marker of androgen activity than TT. Expand
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4
5
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