Association between Insulin-Like Growth Factor-‎‏ ‏‎1 and Severity ‎of Liver Disease in Patients with Liver Cirrhosis ‎

  title={Association between Insulin-Like Growth Factor-‎‏ ‏‎1 and Severity ‎of Liver Disease in Patients with Liver Cirrhosis ‎},
  author={Naglaa El-Toukhy and Mohamed E. Khidr and Mona Youssef},
Background and study aim: Liver cirrhosis is the end result of chronic liver disease and it is a dynamic process that ‎needs close monitoring to prevent its progression and complications. Insulin-like growth ‎factor-1 (IGF-1) is an anabolic hormone secreted mainly by the liver. The aim of this ‎study was to evaluate the serum IGF-1 level and its association with the severity of liver ‎disease in patients with liver cirrhosis‎‎. Method: ‎This study was conducted on 85 patients with liver… 


A Survey of Correlation Between Insulin-Like Growth Factor-I (IGF-I) Levels and Severity of Liver Cirrhosis
The findings showed that IGF-1 can be used as an index for evaluating the severity of cirrhosis; also it could be used for determining the severityof the disease, when liver biopsy is not possible.
Insulin-Like Growth Factor-1 Deficiency and Cirrhosis Establishment
IGF-1 deprivation seriously contributes to the progressive malnutrition of cirrhotic patient, increasing the vulnerability of the liver to establish an inflammatory and oxidative microenvironment with mitochondrial dysfunction, and IGF-1 deficiency in cirrhotics can justify some of the common characteristics of these individuals.
Circulating insulin-like growth factor-binding protein 3 as prognostic biomarker in liver cirrhosis.
Lower IGFBP-3 levels were associated with worse outcomes in patients with cirrhosis, and might represent a promising prognostic tool that can be incorporated in clinical practice.
Clinical significance of serum IGF-I, IGF-II and IGFBP-3 in liver cirrhosis.
Serum IGF-I, IGF-II and IGFBP-3 may provide a new dimension in the assessment of liver dysfunction and be more effective in predicting prognosis than Child-Pugh score alone.
A predictive index for the diagnosis of cirrhosis in hepatitis C based on clinical, laboratory, and ultrasound findings
Cirrhosis can be predicted in patients with chronic hepatitis C by the evaluation of seven clinical, laboratory, and sonographic variables and will be useful for the management and follow-up of hepatitis C patients drastically reducing the indications for biopsy in this context.
Reference ranges of serum IGF-1 and IGFBP-3 levels in a general adult population: results of the Study of Health in Pomerania (SHIP).
  • N. Friedrich, D. Alte, H. Wallaschofski
  • Medicine, Biology
    Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society
  • 2008
Re-weighting the model for end-stage liver disease score components.
Existing MELD coefficient components are significantly different than those calculated from national waiting list data and updated MELD assigns lower weight to creatinine and international normalized ratio and higher weight to bilirubin.