Association between IL-6 and MMP-3 gene polymorphisms and adolescent idiopathic scoliosis: a case-control study.

@article{Aulisa2007AssociationBI,
  title={Association between IL-6 and MMP-3 gene polymorphisms and adolescent idiopathic scoliosis: a case-control study.},
  author={Lorenzo Aulisa and Pierangelo Papaleo and Enrico Pola and Flavia Angelini and Angelo G Aulisa and Francesco Ciro Tamburrelli and Paolo Pola and Carlo Ambrogio Logroscino},
  journal={Spine},
  year={2007},
  volume={32 24},
  pages={2700-2}
}
STUDY DESIGN Case-control study. OBJECTIVE As inflammation plays a key role in the etiology of intervertebral disc degeneration, we suggest a possible contribution of pro-inflammatory gene polymorphisms in the pathogenesis of adolescent idiopathic scoliosis (AIS). SUMMARY OF BACKGROUND DATA The nucleus pulposus of scoliotic discs responds to exogenous stimuli by secreting interleukin-6 (IL-6) and other inflammatory cytokines. The association between matrix metalloproteinases (MMPs) and disc… CONTINUE READING

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