Association between HLA‐B*1502 Allele and Antiepileptic Drug‐Induced Cutaneous Reactions in Han Chinese

@article{Man2007AssociationBH,
  title={Association between HLA‐B*1502 Allele and Antiepileptic Drug‐Induced Cutaneous Reactions in Han Chinese},
  author={Celeste B.L. Man and Patrick Kwan and Larry Baum and Evelyn Yu and Kin Mang Lau and Alice Suk-Hang Cheng and Margaret H L Ng},
  journal={Epilepsia},
  year={2007},
  volume={48}
}
Summary:  A previous study conducted in Taiwan found a 100% association between HLA‐B*1502 allele and carbamazepine‐induced Stevens‐Johnson syndrome (SJS) in Han Chinese subjects, with an extremely high odds ratio compared with carbamazepine‐tolerant subjects (odds ratio = 2,504). We examined this association in 24 Hong Kong Han Chinese subjects who had cutaneous adverse reactions induced by different antiepileptic drugs (AEDs). They were matched with 48 AED‐tolerant controls. HLA‐B*1502 was… Expand

Paper Mentions

Interventional Clinical Trial
The primary objective is to determine if the medication Carbamazepine, can be used as a therapy for patients with severe liver disease due to Alpha-1-Antitrypsin Deficiency .  
ConditionsAlpha-1-antitrypsin Deficiency, Liver Cirrhosis
InterventionDrug
Association between HLA‐B*1502 and carbamazepine‐induced severe cutaneous adverse drug reactions in a Thai population
TLDR
Results from this study suggest that HLA‐B*1502 may be a useful pharmacogenetic test for screening Thai individuals who may be at risk for CBZ‐induced SJS and TEN. Expand
Pilot association study of oxcarbazepine-induced mild cutaneous adverse reactions with HLA-B*1502 allele in Chinese Han population
TLDR
It is recommended that HLA-B*1502 allele should be tested for patients with OXC-induced MPE before changing to other AEDs, and AED’s with similar chemical structure should be avoided in individuals who test positive for it. Expand
Association of HLA-B*1502 allele and carbamazepine-induced Stevens-Johnson syndrome among Indians.
TLDR
This study suggests an association between HLA-B*1502 and carbamazepine-induced SJS in Indian patients. Expand
Association between HLA-B*1502 allele and carbamazepine-induced severe cutaneous adverse reactions in Han people of southern China mainland
TLDR
The data showed that HLA-B*1502 allele is strongly associated with carbamazepine-induced SJS/TEN but not MPE in Han Chinese of southern China mainland. Expand
Association of HLA-B*1502 and *1511 allele with antiepileptic drug-induced Stevens-Johnson syndrome in central China
  • Dan Sun, Chunying Yu, +6 authors Hui-Hui Xiang
  • Medicine
  • Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban
  • 2014
TLDR
It was suggested that the association between the CBZ-induced SJS and HLA-B*1502 allele in Han Chinese children can extend to other aromatic AEDs including OXC and PB related SJS. Expand
Association of HLA-B*1502 and *1511 allele with antiepileptic drug-induced Stevens-Johnson syndrome in central China
Previous studies have demonstrated a strong association between carbamazepine (CBZ)-induced Stevens-Johnson syndrome (SJS) and HLA-B*1502 in Han Chinese. Here, we extended the study of HLA-B*1502Expand
The HLA‐A*2402/Cw*0102 haplotype is associated with lamotrigine‐induced maculopapular eruption in the Korean population
TLDR
Findings suggest the presence of HLA‐related genetic risk factors for LTG‐induced MPE in the Korean population. Expand
Association of HLA-B*1502 allele and carbamazepine- induced severe adverse cutaneous drug reaction among Asians, a review
TLDR
There is urgent need for further studies to determine the prevalence of SJS/TEN, and HLA B*1502 in the various ethnic groups in Asia, and its association with carbamazepine-induced SJS-TEN in each of these ethnic groups. Expand
Association between HLA and Stevens–Johnson Syndrome Induced by Carbamazepine in Southern Han Chinese: Genetic Markers besides B*1502?
TLDR
Given the association between HLA‐B*1502 and CBZ‐induced SJS/TEN, genetic testing before initiating CBZ therapy is suggested in Han Chinese population, and physicians should also be vigilant about SJS /TEN in those negative for HLA•B* 1502. Expand
HLA‐A31 strongly associates with carbamazepine‐induced adverse drug reactions but not with carbamazepine‐induced lymphocyte proliferation in a Japanese population
TLDR
It is suggested that HLA‐A31 is strongly associated with CBZ‐induced ADR in the Japanese, but does not determine CBz‐induced lymphocyte proliferation. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 16 REFERENCES
Genetic susceptibility to carbamazepine-induced cutaneous adverse drug reactions
  • S. Hung, W. Chung, +16 authors Yuan-Tsong Chen
  • Medicine
  • Pharmacogenetics and genomics
  • 2006
TLDR
The data suggest that HLA-B*1502 could contribute to the pathogenesis ofCBZ-SJS/TEN, and that genetic susceptibility to CBZ-induced cADRs is phenotype-specific. Expand
A marker for Stevens-Johnson syndrome …: ethnicity matters
TLDR
Preliminary results from a European study of 12 carbamazepine-induced SJS/TEN cases (RegiSCAR) show that although the HLA region may contain important genes for SJS, the Hla-B*1502 allele is not a universal marker for this disease and that ethnicity matters. Expand
Risk of serious cutaneous disorders after initiation of use of phenytoin, carbamazepine, or sodium valproate: A record linkage study
TLDR
During the first few weeks of initiating therapy with phenytoin or carbamazepine, the clinician should be aware of the uncommon but not rare possibility that a cutaneous eruption could evolve into a significantly more serious reaction. Expand
Medical genetics: A marker for Stevens–Johnson syndrome
TLDR
It is shown that there is a strong association in Han Chinese between a genetic marker, the human leukocyte antigen HLA–B*1502, and Stevens–Johnson syndrome induced by carbamazepine, a drug commonly prescribed for the treatment of seizures. Expand
Hypersensitivity reactions to carbamazepine: characterization of the specificity, phenotype, and cytokine profile of drug-specific T cell clones.
TLDR
Drug-specific T cells in CBZ-hypersensitive patients that are phenotypically different from T cells involved in other serious cutaneous adverse drug reactions are characterized. Expand
Life-threatening adverse events of antiepileptic drugs
TLDR
Future epidemiological, chemical, and genetic research might provide methods for ascertaining which patients are at risk, so undue exposure can be avoided and the very rare occurrence of life threatening events should not limit treatment decision-making. Expand
Lamotrigine‐Associated Rash: Risk/Benefit Considerations in Adults and Children
Summary: Purpose: Lamotrigine (LTG) is an antiepileptic drug (AED) recently released in several countries. It is effective for a variety of seizure types in adults and children both as an add‐onExpand
Activation of T cells by carbamazepine and carbamazepine metabolites.
TLDR
These data show that carbamazepine and certain stable carbazepine metabolites stimulate T cells rapidly via a direct interaction with MHC and specific T-cell receptors, providing a rationale for cross-sensitivity between the 2 drugs. Expand
Serum anticonvulsant concentrations and the risk of drug induced skin eruptions.
TLDR
High initial serum concentrations of these drugs appeared to be a factor influencing the occurrence of drug-induced skin reactions to phenytoin and carbamazepine. Expand
Toxic epidermal necrolysis: effector cells are drug-specific cytotoxic T cells.
TLDR
The results strongly suggest that drug-specific, MHC class I-restricted, perforin/granzyme-mediated cytotoxicity probably has a primary role in TEN. Expand
...
1
2
...