Association between Growth Hormone-Insulin-Like Growth Factor-1 Axis Gene Polymorphisms and Short Stature in Chinese Children

  title={Association between Growth Hormone-Insulin-Like Growth Factor-1 Axis Gene Polymorphisms and Short Stature in Chinese Children},
  author={Yanhong Zhang and Mei Zhang and Yuntian Chu and Baolan Ji and Qian Shao and Bo Ban},
  journal={BioMed Research International},
Objective This study was designed to analyze the association between the growth hormone-insulin-like growth factor-1 (GH-IGF-1) axis gene polymorphisms and short stature in Chinese children. Methods 181 growth hormone deficiency (GHD) patients and 206 normal stature controls were enrolled to attend this study. Five single-nucleotide polymorphisms in the GH receptor (GHR) and 5 SNPs within the GH-signaling pathway were genotyped by matrix-assisted laser desorption/ionization time of flight mass… Expand
1 Citations
Evaluation of Safety and Efficacy of Growth Hormone Therapy by IGF-1 Z Score in Children with Short Stature
IGF-1-based GH dosing targeted to age- and gender-adjusted means may save medical costs and offer a more dose-sparing and potentially safer mode of therapy compared with traditional weight-based dosing. Expand


Relationship between growth hormone receptor gene polymorphism and idiopathic short stature in Guangxi Yao nationality children
GHR gene rs4410646,rs2940913,and rs12515480 polymorphisms are not associated with idiopathic short stature in Yao nationality children of Guangxi province. Expand
Association of insulin growth factor-1 receptor gene polymorphisms with genetic susceptibility to idiopathic short stature.
The association between single nucleotide polymorphisms (SNPs) in the insulin-like growth factor-1 receptor (IGF-1R) gene and susceptibility to idiopathic short stature (ISS) was investigated and different clinical phenotypes of ISS may be associated with SNPs of IGF- 1R. Expand
Associations of single nucleotide polymorphisms of growth hormone receptor with susceptibility to idiopathic short stature
GHR plays a role in the growth promotion effect mediated by growth hormone, and 3 SNP sites of human GHR gene may be related to genetic susceptibility to ISS. Expand
SNPs within the GH-signaling pathway are associated with the early IGF1 response to GH replacement therapy in GHD adults.
Testing the hypothesis that single-nucleotide polymorphisms in genes within the GH signaling pathway influence the serum IGF1 response to GH replacement in GHD adults indicates that common genetic variants in theGH signaling pathway may be of functional relevance to the response toGH replacement. Expand
The growth hormone receptor exon 3-deleted/full-length polymorphism and response to growth hormone therapy in prepubertal idiopathic short children.
The results do not suggest that the d3-GHR genotype is associated with increased sensitivity to GH in children with ISS, and the common GHR d3/fl polymorphism is probably not a cause of DICT inChildren with ISS. Expand
Growth hormone receptor (GHR) exon 3 polymorphism status detection by dual-enzyme-linked immunosorbent assay (ELISA).
This dual ELISA against tGHBP and E3(+)GHBP can be used as an alternative method for determining GHRd3 polymorphism status and it is observed that d3/d3 subjects had significantly lower serum levels of t GHBP compared with fl/fl andd3/fl genotypes. Expand
MECHANISMS IN ENDOCRINOLOGY: The multiple facets of GHRH/GH/IGF-I axis: lessons from lifetime, untreated, isolated GH deficiency due to a GHRH receptor gene mutation.
These subjects exhibit markedly reduced GH responsiveness to stimulatory tests, and anterior pituitary hypoplasia, and have high low density lipoprotein cholesterol and C-reactive protein levels, but maintain increased insulin sensitivity, and do not show premature atherosclerosis. Expand
Insulin-Like Growth Factor-I is a Marker for the Nutritional State.
The effects of nutrition on the GH/IGF-I axis is summarized, and the clinical implications of these interactions throughout childhood are reviewed, both in under-nutrition and over-nutrition. Expand
Heterozygous IGFALS Gene Variants in Idiopathic Short Stature and Normal Children: Impact on Height and the IGF System
Findings suggest that heterozygous IGFALS gene variants could be responsible for short stature in a subset of ISS children with diminished levels of IGF-1, IGFBP-3 and ALS. Expand
Towards identification of molecular mechanisms of short stature
Two strategies that will likely be offered with increasing frequency are highlighted: unbiased genetic technologies including array analysis for copy number variation and whole exome/genome sequencing and epigenetic alterations of key genomic loci. Expand