Association between GRB2/Sos and insulin receptor substrate 1 is not sufficient for activation of extracellular signal-regulated kinases by interleukin-4: implications for Ras activation by insulin.

@article{Pruett1995AssociationBG,
  title={Association between GRB2/Sos and insulin receptor substrate 1 is not sufficient for activation of extracellular signal-regulated kinases by interleukin-4: implications for Ras activation by insulin.},
  author={W Pruett and Yuhui Yuan and Elizabeth A McI Rose and A G Batzer and Naomoto Harada and Edward Y Skolnik},
  journal={Molecular and cellular biology},
  year={1995},
  volume={15 3},
  pages={1778-85}
}
Insulin receptor substrate 1 (IRS-1) mediates the activation of a variety of signaling pathways by the insulin and insulin-like growth factor 1 receptors by serving as a docking protein for signaling molecules with SH2 domains. We and others have shown that in response to insulin stimulation IRS-1 binds GRB2/Sos and have proposed that this interaction is important in mediating Ras activation by the insulin receptor. Recently, it has been shown that the interleukin (IL)-4 receptor also… CONTINUE READING

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