Association between Frequency of Chromosomal Aberrations and Cancer Risk Is Not Influenced by Genetic Polymorphisms in GSTM1 and GSTT1

@article{Rossi2009AssociationBF,
  title={Association between Frequency of Chromosomal Aberrations and Cancer Risk Is Not Influenced by Genetic Polymorphisms in GSTM1 and GSTT1},
  author={A. Rossi and I. Hansteen and C. Skjelbred and M. Ballardin and V. Maggini and E. Murgia and A. Tomei and P. Viarengo and L. Knudsen and R. Barale and H. Norppa and S. Bonassi},
  journal={Environmental Health Perspectives},
  year={2009},
  volume={117},
  pages={203 - 208}
}
Background The frequency of chromosomal aberrations (CA) in peripheral blood lymphocytes of healthy individuals has been associated with cancer risk. It is presently unclear whether this association is influenced by individual susceptibility factors such as genetic polymorphisms of xenobiotic-metabolizing enzymes. Objectives To evaluate the role of polymorphisms in glutathione S-transferase (GST) M1 (GSTM1) and theta 1 (GSTT1) as effect modifiers of the association between CA and cancer risk… Expand
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