Association between DNA methylation and shortened survival in patients with advanced colorectal cancer treated with 5-fluorouracil based chemotherapy.

@article{Shen2007AssociationBD,
  title={Association between DNA methylation and shortened survival in patients with advanced colorectal cancer treated with 5-fluorouracil based chemotherapy.},
  author={Lanlan Shen and Paul J. Catalano and Al Bowen Benson and Peter J. O'dwyer and Stanley R. Hamilton and Jean-Pierre Issa},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2007},
  volume={13 20},
  pages={6093-8}
}
PURPOSE There are no good genomic markers of survival in patients with advanced colorectal cancer. The CpG island methylator phenotype (CIMP) marks a distinctive pathway in colorectal cancer. We sought to determine the prognostic significance of CIMP in advanced colorectal cancer patients treated with 5-fluorouracil (5-FU) in an Eastern Cooperative Oncology Group clinical trial. EXPERIMENTAL DESIGN We studied 188 patients enrolled on protocol E2290, a five-arm trial comparing 5-FU, 5-FU in… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 86 extracted citations

Colorectal cancer: epigenetic alterations and their clinical implications.

Biochimica et biophysica acta. Reviews on cancer • 2017
View 1 Excerpt

Similar Papers

Loading similar papers…