Association between Cyclin Dl ( CCND 1 ) Gene Amplification and Human Papillomavirus Infection in Human Laryngeal Squamous Cell Carcinoma

Head and neck squamous cell carcinomas (SCCs) seem to follow a multistep process of carcinogenesis in which chemical and/or viral agents are associated with specific genetic alterations. The prevalence of human papillomavi. rus (HPV) infection and the amplification of the cyclin Dl (CCND1) gene were evaluated in a series of 75 laryngeal SCCs by PCR with HPV… (More)