Association between Common Germline Genetic Variation in 94 Candidate Genes or Regions and Risks of Invasive Epithelial Ovarian Cancer

@article{Quaye2009AssociationBC,
  title={Association between Common Germline Genetic Variation in 94 Candidate Genes or Regions and Risks of Invasive Epithelial Ovarian Cancer},
  author={L. A. N. Quaye and Jonathan P. Tyrer and Susan J Ramus and Honglin Song and Eva L Wozniak and Richard A. Dicioccio and Valerie A McGuire and Estrid V. S. H\ogdall and Claus Kim H\ogdall and Jan Blaakaer and Ellen L. Goode and Joellen Martha Schildkraut and Douglas F. Easton and Susanne Kr{\"u}ger-Kjaer and Alice S. Whittemore and Simon A. Gayther and Paul P. D. Pharoah},
  journal={PLoS ONE},
  year={2009},
  volume={4},
  pages={280 - 284}
}
BACKGROUND Recent studies have identified several single nucleotide polymorphisms (SNPs) in the population that are associated with variations in the risks of many different diseases including cancers such as breast, prostate and colorectal. For ovarian cancer, the known highly penetrant susceptibility genes (BRCA1 and BRCA2) are probably responsible for only 40% of the excess familial ovarian cancer risks, suggesting that other susceptibility genes of lower penetrance exist. METHODS We have… CONTINUE READING
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