Association between CYP17 polymorphisms and the development of breast cancer.

  title={Association between CYP17 polymorphisms and the development of breast cancer.},
  author={Kathy J. Helzlsouer and Han Yao Huang and Paul T. Strickland and Sandy C Hoffman and Anthony J. Alberg and George W. Comstock and Douglas A. Bell},
  journal={Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology},
  volume={7 10},
A nested case-control study was conducted to determine whether a genetic polymorphism in the CYP17 gene, which encodes for an enzyme that mediates steroid hormone metabolism, was associated with an increased risk of breast cancer. No association was found between the presence of an A2 allele and the subsequent development of breast cancer [A1/A2 odds ratio, 0.61 (95% confidence interval, 0.33-1.14); A2/A2 odds ratio, 0.89 (95% confidence interval, 0.41-1.95)]. No significant association was… CONTINUE READING

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