Association between CCR5 genotype and the clinical course of HIV-1 infection.

  title={Association between CCR5 genotype and the clinical course of HIV-1 infection.},
  author={Ana Maria de Roda Husman and Maarten Koot and Marion I Cornelissen and Ireneus P M Keet and Margreet Brouwer and S. M. Broersen and Margreet Bakker and Marijke T. L. Roos and Maria Prins and Frank de Wolf and Roel A. Coutinho and Frank A Miedema and Jaap Goudsmit and Hanneke Schuitemaker},
  journal={Annals of internal medicine},
  volume={127 10},
BACKGROUND Heterozygosity for a 32-nucleotide deletion in the C-C chemokine receptor 5 gene (CCR5 delta 32) is associated with delayed disease progression in persons infected with HIV-1. OBJECTIVE To compare the predictive value of CCR5 genotype with that of established markers in the clinical course of HIV-1 infection. DESIGN Retrospective longitudinal study and nested case-control study. The latter included only long-term survivors, who were individually matched with progressors… CONTINUE READING
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