Association between C4d staining in renal transplant biopsies, production of donor-specific HLA antibodies, and graft outcome.

@article{Worthington2007AssociationBC,
  title={Association between C4d staining in renal transplant biopsies, production of donor-specific HLA antibodies, and graft outcome.},
  author={Judith E Worthington and Anna McEwen and Lorna Jean McWilliam and Michael L Picton and Susan St Martin},
  journal={Transplantation},
  year={2007},
  volume={83 4},
  pages={398-403}
}
BACKGROUND We carried out a retrospective study of C4d staining in paraffin sections from renal transplant biopsies to determine the association between C4d staining, donor-specific antibodies (DSA), histological features, and graft outcome. METHODS We studied 92 patients who had been biopsied for graft dysfunction. Biopsies were classified using Banff 97 criteria and features suggestive of antibody-mediated rejection were noted. Paraffin sections were stained with a polyclonal antibody using… CONTINUE READING