Corpus ID: 40863838

Association between BIM deletion polymorphism and the risk of non-small cell lung cancer in Chinese

  title={Association between BIM deletion polymorphism and the risk of non-small cell lung cancer in Chinese},
  author={Jinjing Xia and L. Xiong and T. Chu and J. Ye and H. Bai and B. Yan and R. Zhong and M. Shao and Baohui Han},
The incidence rate of lung cancer is increasing rapidly recent years. Except smoking, air-pollution and other environmental cancer-related issues, genetic risk sites contribute to lung cancer in another aspect. Previous studies demonstrated 2903-bp deletion polymorphism of BIM was critical in resistance of tyrosine kinase inhibitors (TKI) therapy. Besides, the expression level of BIM played an important role in cancers. The deletion polymorphism could lead to similar effect as low expression… Expand
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