Association between Ala54Thr substitution of the fatty acid-binding protein 2 gene with insulin resistance and intra-abdominal fat thickness in Japanese men

@article{Yamada1997AssociationBA,
  title={Association between Ala54Thr substitution of the fatty acid-binding protein 2 gene with insulin resistance and intra-abdominal fat thickness in Japanese men},
  author={Kazuya Yamada and Xin Yuan and Shuichi Ishiyama and Kazunori Koyama and Fumito Ichikawa and Ai Koyanagi and Wasaku Koyama and Kenji Nonaka},
  journal={Diabetologia},
  year={1997},
  volume={40},
  pages={706-710}
}
Alanine to threonine substitution at codon 54 of the fatty acid-binding protein 2 (FABP2) gene was recently shown to be associated with insulin resistance in Pima Indians. It has been hypothesized that the mutation may result in enhanced intestinal uptake of fatty acids, and thereby an impairment of insulin action. We analysed the association of the Ala54Thr substitution with insulin sensitivity and abdominal fat thickness in 395 Japanese men aged 50.5 ± 8.8 years (mean ± SD) with a body mass… CONTINUE READING
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