Association between APOE epsilon4 allele and vascular dementia: The Cache County study.

@article{Chuang2010AssociationBA,
  title={Association between APOE epsilon4 allele and vascular dementia: The Cache County study.},
  author={Y F Chuang and Kathleen M. Hayden and Maria C. Norton and JoAnn T. Tschanz and John C. S. Breitner and Kathleen Welsh-Bohmer and Peter P. Zandi},
  journal={Dementia and geriatric cognitive disorders},
  year={2010},
  volume={29 3},
  pages={248-53}
}
BACKGROUND The APOE epsilon4 allele is an established risk factor for Alzheimer's disease, but reports of its association with vascular dementia (VaD) have been inconsistent. We examined the relationship between APOE epsilon4 allele and the risk of incident VaD in a large, population-based cohort of elderly adults with up to 10 years of follow-up between 1995 and 2005. METHODS A total of 3,424 elderly men and women free of dementia were genotyped at the baseline assessment. Incident VaD was… CONTINUE READING

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