Association between AKT1 gene and Parkinson's disease: a protective haplotype.

  title={Association between AKT1 gene and Parkinson's disease: a protective haplotype.},
  author={Georgia Xiromerisiou and Georgios M. Hadjigeorgiou and Alexandros Papadimitriou and Evaggelos Katsarogiannis and Vasiliki Gourbali and Andrew Singleton},
  journal={Neuroscience letters},
  volume={436 2},
Variation in AKT1 has been associated with schizophrenia, bipolar disease and type II diabetes. The aim of the present study was to investigate the potential role of variability within AKT1 as a risk factor for Parkinson's disease (PD). We performed a case-control association analysis of AKT1 in a Greek cohort of PD using four tagging SNPs and five constructed haplotypes. To assess the structure of this locus in different populations we have performed linkage disequilibrium (LD) analysis using… CONTINUE READING


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