Association between ABCC2 gene haplotypes and tenofovir-induced proximal tubulopathy.

  title={Association between ABCC2 gene haplotypes and tenofovir-induced proximal tubulopathy.},
  author={Hassane Izzedine and J. C. Hulot and Eric Villard and Catherine Goyenvalle and St{\'e}phanie Dominguez and Jade Ghosn and Marc Antoine Valantin and Philippe P Lechat and And Gilbert Deray},
  journal={The Journal of infectious diseases},
  volume={194 11},
BACKGROUND Tenofovir disoproxil fumarate (TDF) may induce renal proximal tubulopathy (rPT). There are no data on pharmacogenomic predictors of rPT in the genes encoding the multidrug-resistance protein (MRP) 2 and MRP4 transporters. METHODS Mutational screening of the genes for MRP2 (ABCC2) and MRP4 (ABCC4) was performed using genomic DNA from 13 human immunodeficiency virus type 1 (HIV-1)-infected patients (group 1) presenting with TDF-induced rPT. Concomitantly, 17 unrelated HIV-1-infected… CONTINUE READING
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