Association between ABCB1 genotype and seizure outcome in Collies with epilepsy.

  title={Association between ABCB1 genotype and seizure outcome in Collies with epilepsy.},
  author={Karen R Mu{\~n}ana and Julie A Nettifee-Osborne and Robert L. Bergman and Katrina L. Mealey},
  journal={Journal of veterinary internal medicine},
  volume={26 6},
BACKGROUND Medically refractory seizures are an important problem in both humans and dogs with epilepsy. Altered expression of ABCB1, the gene encoding for p-glycoprotein (PGP), has been proposed to play a role in drug-resistant epilepsy. HYPOTHESIS Heterogeneity of the ABCB1 gene is associated with seizure outcome in dogs with epilepsy. ANIMALS Twenty-nine Collies with epilepsy being treated with antiepileptic drugs (AEDs). METHODS Prospective and retrospective cohort study. Dogs were… CONTINUE READING
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