Association between 5-HT(2A) receptor polymorphism and psychotic symptoms in Alzheimer's disease.

@article{Nacmias2001AssociationB5,
  title={Association between 5-HT(2A) receptor polymorphism and psychotic symptoms in Alzheimer's disease.},
  author={Benedetta Nacmias and Andrea Tedde and Paolo Forleo and Silvia Piacentini and Bianca Maria Guarnieri and Antonella Natalia Bartoli and L. Ortenzi and Concetta Petruzzi and Antonio Serio and Gabriella Marcon and Sandro Sorbi},
  journal={Biological psychiatry},
  year={2001},
  volume={50 6},
  pages={472-5}
}
BACKGROUND The aim of this study is to analyze the segregation of the 102T/C polymorphism in the serotonin 2A receptor gene in patients affected by sporadic and familial Alzheimer's disease (FAD) with and without psychotic symptoms. METHODS The polymorphism was analyzed in 275 subjects. A semistructured interview was used to obtain information about delusions, hallucinations, and other specific behavioral signs occurring during the disease. RESULTS Fifty-two percent of AD patients with… CONTINUE READING