Association between 11β-hydroxysteroid dehydrogenase type 1 gene polymorphisms and metabolic syndrome in Bosnian population

INTRODUCTION The enzyme 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) catalyzes the conversion of the hormonally inactive cortisone to active cortisol, thus facilitating glucocorticoid receptor activation in target tissues. Increased expression of 11beta-HSD1 in adipose tissue has been associated with obesity and insulin resistance. In this study… CONTINUE READING