Association and multiple interaction analysis among five XRCC1 polymorphic variants in modulating lung cancer risk in North Indian population.

@article{Singh2016AssociationAM,
  title={Association and multiple interaction analysis among five XRCC1 polymorphic variants in modulating lung cancer risk in North Indian population.},
  author={Amrita Singh and Navneet Singh and Digamber Behera and Siddharth Sharma},
  journal={DNA repair},
  year={2016},
  volume={47},
  pages={30-41}
}
XRCC1 is a scaffold protein that provides for interaction of DNA polymerase, DNA ligase and damaged DNA. Genotyping was done for the five non-synonymous and synonymous variants of XRCC1 i.e. XRCC1, Arg194Trp, Pro206Pro, Arg280His, Arg399Gln, Gln632Gln. Logistic regression analysis was used to analyze the association of XRCC1 with lung cancer, followed by… CONTINUE READING