Association and insulin regulated translocation of hormone-sensitive lipase with PTRF.

@article{Aboulaich2006AssociationAI,
  title={Association and insulin regulated translocation of hormone-sensitive lipase with PTRF.},
  author={Nabila Aboulaich and Unn Ortegren and Alexander V. Vener and Peter Str{\aa}lfors},
  journal={Biochemical and biophysical research communications},
  year={2006},
  volume={350 3},
  pages={657-61}
}
Polymerase I and transcript release factor (PTRF) is in human adipocytes mainly localized at the plasma membrane. This localization was under control of insulin, which translocated PTRF to the cytosol and nucleus, indicating a novel role for PTRF in insulin transcriptional control. In the plasma membrane PTRF was specifically bound to a triacylglycerol-metabolizing subclass of caveolae containing hormone-sensitive lipase (HSL). In response to insulin PTRF was translocated to the cytosol in… CONTINUE READING

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