Association and differential role of PRSS1 and SPINK1 mutation in early-onset and late-onset idiopathic chronic pancreatitis in Chinese subjects.

@article{Chang2009AssociationAD,
  title={Association and differential role of PRSS1 and SPINK1 mutation in early-onset and late-onset idiopathic chronic pancreatitis in Chinese subjects.},
  author={Y. H. Chang and S Y Wei and L P-C and Y-W Tien and I-S Jan and Y-N Su and J M Wong and M-C Chang},
  journal={Gut},
  year={2009},
  volume={58 6},
  pages={885}
}
Chronic pancreatitis (CP) may be associated with genetic susceptibility. We read with interest the article by Mahurkar et al (Gut 2006;55:1270–5) which described the role of pancreatic secretory trypsin inhibitor (SPINK1) gene mutation and cathepsin B gene polymorphisms in tropical calcific pancreatitis. Mutations in the cationic trypsinogen gene (PRSS1) and SPINK1 gene have been reported to be associated with different types of pancreatitis. However, controversial data also exist. The… CONTINUE READING
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