Association and activation of Jak-Tyk kinases by CNTF-LIF-OSM-IL-6 beta receptor components.

@article{Stahl1994AssociationAA,
  title={Association and activation of Jak-Tyk kinases by CNTF-LIF-OSM-IL-6 beta receptor components.},
  author={Neil Stahl and T G Boulton and Thomas Farruggella and Nancy Y Ip and Samuel H Davis and Bruce A. Witthuhn and Frederick W. Quelle and Olli Silvennoinen and Giovanna Barbieri and Sandra Pellegrini},
  journal={Science},
  year={1994},
  volume={263 5143},
  pages={92-5}
}
A recently defined family of cytokines, consisting of ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), oncostatin M (OSM), and interleukin-6 (IL-6), utilize the Jak-Tyk family of cytoplasmic tyrosine kinases. The beta receptor components for this cytokine family, gp130 and LIF receptor beta, constitutively associate with Jak-Tyk kinases. Activation of these kinases occurs as a result of ligand-induced dimerization of the receptor beta components. Unlike other cytokine… CONTINUE READING
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