Association and Stoichiometry of KATP Channel Subunits

  title={Association and Stoichiometry of KATP Channel Subunits},
  author={John P. Clement and Kumud Kunjilwar and Gabriela E. Gonz{\'a}lez and Mathias Schwanstecher and Uwe Panten and Lydia Aguilar-Bryan and Joseph J. Bryan},
ATP-sensitive potassium channels (K(ATP) channels) are heteromultimers of sulfonylurea receptors (SUR) and inwardly rectifying potassium channel subunits (K(IR)6.x) with a (SUR-K(IR)6.x)4 stoichiometry. Association is specific for K(IR)6.x and affects receptor glycosylation and cophotolabeling of K(IR)6.x by 125I-azidoglibenclamide. Association produces digitonin stable complexes with an estimated mass of 950 kDa. These complexes can be purified by lectin chromatography or by using Ni2… CONTINUE READING

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Mutations in the sulfonylurea receptor gene in familial hyperinsulinemic hypoglycemia

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