Association analysis of the glycogen synthase kinase-3beta gene in bipolar disorder.

@article{Nishiguchi2006AssociationAO,
  title={Association analysis of the glycogen synthase kinase-3beta gene in bipolar disorder.},
  author={Naoki Nishiguchi and Gerome Breen and Carsten Russ and David St Clair and David Collier},
  journal={Neuroscience letters},
  year={2006},
  volume={394 3},
  pages={243-5}
}
Glycogen synthase kinase-3beta (GSK3beta) is a target of lithium as well as sodium valproate, both of which are effective mood stabilizing prophylatics/treatments for bipolar disorder, a highly heritable psychiatric disorder. Though it is not clear whether the mood stabilizing effects of these drugs act directly through GSK3beta, it is a good candidate for mediating at least part of lithium's action, and is an aetiological candidate gene for the disease itself. Recently, a potential locus for… CONTINUE READING
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