Association analysis of the LAG3 and CD4 genes in multiple sclerosis in two independent populations

@article{Lundmark2006AssociationAO,
  title={Association analysis of the LAG3 and CD4 genes in multiple sclerosis in two independent populations},
  author={Frida Lundmark and Hanne Flinstad Harbo and Elisabeth Gulowsen Celius and Janna Saarela and Pameli Datta and Annette Bang Oturai and Cecilia M. Lindgren and Thomas Masterman and Hugh Salter and Jan Hillert},
  journal={Journal of Neuroimmunology},
  year={2006},
  volume={180},
  pages={193-198}
}
We have investigated the genetic involvement of the CD4 and the LAG3 genes, two appealing candidates for MS due to their suggested role in MS pathology. We genotyped a Swedish case-control material consisting of 920 MS patients and 778 controls in an initial study of CD4, three SNPs showed a significant association with MS. An independent material consisting of 1720 Nordic MS patients and 1416 controls were used for confirmation of associated markers in CD4 and to do a confirmative study of the… Expand
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