Association analysis of the DRD4 and COMT genes in methamphetamine abuse.

@article{Li2004AssociationAO,
  title={Association analysis of the DRD4 and COMT genes in methamphetamine abuse.},
  author={Tao Li and Chi-ken Chen and Xun Hu and David Michael Ball and Shih-Ku Lin and Wai Leong Chen and Pak Chung Sham and Elizabeth. Loh and Robin M. Murray and David A. Collier},
  journal={American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics},
  year={2004},
  volume={129B 1},
  pages={
          120-4
        }
}
We analyzed two polymorphisms in genes encoding proteins of the dopamine system, the Val158Met polymorphism in the catechol-O-methyltransferase gene and the 120-bp VNTR polymorphism in the promoter of the dopamine D4 receptor gene for association with methamphetamine abuse. We used a case/control design with 416 methamphetamine abusing subjects and 435 normal controls. All subjects were Han Chinese from Taiwan. We found an excess of the high activity Val158 allele in the methamphetamine abuser… CONTINUE READING
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