Association analysis of polymorphisms in serotonin 1B receptor (HTR1B) gene with heroin addiction: a comparison of molecular and statistically estimated haplotypes.

@article{Proudnikov2006AssociationAO,
  title={Association analysis of polymorphisms in serotonin 1B receptor (HTR1B) gene with heroin addiction: a comparison of molecular and statistically estimated haplotypes.},
  author={Dmitri Proudnikov and K Steven Laforge and Heather L Hofflich and Mark A. Levenstien and Derek Gordon and Sandra M Barral and J{\"u}rg Ott and Mary Jeanne Kreek},
  journal={Pharmacogenetics and genomics},
  year={2006},
  volume={16 1},
  pages={25-36}
}
OBJECTIVES 5-Hydroxytryptamine (serotonin)-1B receptors (HTR1B) may play an important role in psychiatric disorders and drug and alcohol dependence. In this study we report on genotype, molecular haplotype and statistically estimated haplotype analyses of previously identified polymorphisms in positions -261T>G, -161A>T, 129C>T, 861G>C and 1180A>G of the HTR1B gene in ethnically diverse populations (African-Americans, Caucasians, Hispanics and Asians) including 235 former heroin addicts and 161… CONTINUE READING