Association analysis of UBE3C polymorphisms in Korean aspirin-intolerant asthmatic patients.

  title={Association analysis of UBE3C polymorphisms in Korean aspirin-intolerant asthmatic patients.},
  author={Jin Sol Lee and Jeong Hyun Kim and Joon Seol Bae and Jason Yongha Kim and Tae Joon Park and Charisse Flerida A Pasaje and Byung Park and Hyun Sub Cheong and Jong Sook Park and Soo-taek Uh and Mi-Kyeong Kim and Inseon S. Choi and Sang Heon Cho and B. W. Choi and Choon-Sik Park and Hyoung Doo Shin},
  journal={Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology},
  volume={105 4},
BACKGROUND Aspirin-intolerant asthma (AIA), as an asthma phenotype that involves the upper or lower airways, occurs from excessive leukotriene production on administration of nonsteroidal anti-inflammatory drugs. The UBE3C gene on chromosome 7 is a member of the E3 ligase enzymes and is implicated in the ubiquitin-proteasome pathway. This pathway is involved in immune responses to inflammation, including asthma. OBJECTIVE To investigate whether the UBE3C polymorphisms are associated with the… CONTINUE READING


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