Association analysis of GABA receptor subunit genes on 5q33 with heroin dependence in a Chinese male population.

Abstract

GABAA receptor subunit genes clustered on 5q33 play a role in the development of alcoholism and methamphetamine use disorder without psychosis. The present study explored the possible contribution of the same subunit genes to the development of heroin dependence. Single nucleotide polymorphisms (SNPs) of the GABAA receptor subunits GABRB2, GABRA6, GABRA1, and GABRG2 were examined in 178 male Han Chinese heroin-dependent and 170 male control subjects. A significant difference in allele frequency for the SNP rs211014 in the GABAAgamma2 receptor subunit gene between cases and controls was identified (P = 0.015). A possible mechanism for the involvement of the GABA receptor subunit genes on 5q33 in the development of heroin dependence is discussed.

Cite this paper

@article{Loh2007AssociationAO, title={Association analysis of GABA receptor subunit genes on 5q33 with heroin dependence in a Chinese male population.}, author={E W Loh and Nelson L-S Tang and Dominic T S Lee and Shen - Iuan Liu and Alfreda Stadlin}, journal={American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics}, year={2007}, volume={144B 4}, pages={439-43} }