Association analysis for genetic variants of the NMDA receptor 2b subunit (GRIN2B) and Parkinson's disease

@article{Tsai2002AssociationAF,
  title={Association analysis for genetic variants of the NMDA receptor 2b subunit (GRIN2B) and Parkinson's disease},
  author={S.-J. Tsai and H. Liu and T. Liu and C.-Y. Cheng and C Hong},
  journal={Journal of Neural Transmission},
  year={2002},
  volume={109},
  pages={483-488}
}
Recent studies have implicated N-methyl-D-aspartate (NMDA) receptor dysfunction in the pathogenesis and treatment of Parkinson's disease (PD). The NMDA receptor is composed of several subunits, of which, the receptor 2b subunit (GRIN2B) is of particular significance for PD. This subunit is found enriched in the basal ganglia, and PD-monotherapy potential has been determined for GRIN2B antagonists. For this study of a sample population consisting of 101 PD patients and 108 controls, we tested… CONTINUE READING
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GRIN2B and Parkinson’s disease

  • S.-J. Tsai
  • 2001

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