Association analysis between K and -116A variants of butyrylcholinesterase and Alzheimer's disease in a Brazilian population.

@article{SimoSilva2013AssociationAB,
  title={Association analysis between K and -116A variants of butyrylcholinesterase and Alzheimer's disease in a Brazilian population.},
  author={Daiane Priscila Sim{\~a}o-Silva and Paulo Henrique Ferreira Bertolucci and Roger William de L{\'a}bio and Spencer Luiz Marques Pay{\~a}o and Lupe Furtado-Alle and Ricardo Lehtonen Rodrigues de Souza},
  journal={Chemico-biological interactions},
  year={2013},
  volume={203 1},
  pages={358-60}
}
In Alzheimer's disease (AD) a reduction in acetylcholinesterase (AChE) and an increase in butyrylcholinesterase (BChE) activity are observed. K variant (539T) is the most common variant of the BCHE gene and, although controversial, several studies reported association between K variant and AD. Previous results showed that the K variant alone is not capable of diminishing BChE activity, depending on the presence of the -116A variant. Considering that, we conducted a case-control association… CONTINUE READING

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