• Corpus ID: 20115253

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

  title={Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index},
  author={Elizabeth K. Speliotes and Cristen J. Willer and Sonja I. Berndt and Keri L. Monda and Gudmar Thorleifsson and Anne U. Jackson and Hana Lango Allen and Cecilia M. Lindgren and Jian’an Luan and Reedik Maegi and Joshua C. Randall and Sailaja Vedantam and Thomas W. Winkler and Lu Qi and Tsegaselassie Workalemahu and Iris M. Heid and Valgerdur Steinthorsdottir and Heather M. Stringham and Michael N. Weedon and Eleanor Wheeler and Andrew R. Wood and Teresa Ferreira and Robert J. Weyant and Ayellet V. Segr{\`e} and Karol Estrada and Liming Liang and James Nemesh and Ju-Hyun Park and Stefan Gustafsson and Tuomas O. Kilpelaenen and Jian Yang and Nabila Bouatia-Naji and T{\~o}nu Esko and Mary F. Feitosa and Zolt{\'a}n Kutalik and Massimo Mangino and Soumya Raychaudhuri and Andr{\'e} Scherag and Albert Vernon Smith and Ryan Welch and Jing Hua Zhao and Katja K. H. Aben and Devin M Absher and Najaf Amin and Anna L. Dixon and Eva Fisher and Nicole L. Glazer and Michael E Goddard and Nancy L. Heard-Costa and Volker Hoesel and Jouke- Jan Hottenga and {\AA}sa Johansson and Toby Johnson and Shamika Ketkar and Claudia Lamina and Shengxu Li and Miriam F. Moffatt and Richard H. Myers and Narisu Narisu and John R. B. Perry and Marjolein J. Peters and Michael H. Preuss and Samuli Ripatti and Fernando Rivadeneira and Camilla Helene Sandholt and Laura J. Scott and Nicholas John Timpson and Jonathan P. Tyrer and Sophie H van Wingerden and Richard M Watanabe and Charles White and Fredrik Wiklund and Cristina Barlassina and Daniel I. Chasman and Mark Emmanuel Cooper and John-Olov Jansson and Robert Lawrence and Niina Pellikka and Inga Prokopenko and Jianxin Shi and Elisabeth Thiering and Helene Alavere and Maria Teresa Sciarrone Alibrandi and Peter Almgren and Alice M. Arnold and Thor Aspelund and Larry D. Atwood and Beverley Balkau and Anthony J. Balmforth and Amanda Bennett and Yoav Ben-Shlomo and Richard N. Bergman and S. Bergmann and Heike Biebermann and Alexandra I. F. Blakemore and Tanja Boes and Lori L Bonnycastle and Stefan R. Bornstein and Morris J. Brown and Thomas A. Buchanan and Fabio Busonero and Harry Campbell and Francesco Paolo Cappuccio and Christine Cavalcanti-Proença and Yii-Der I. Chen and Chih-Mei Chen and Peter S. Chines and Robert J. Clarke and Lachlan J. Coin and John M. Connell and Ian N. M. Day and Martin den Heijer and Jubao Duan and Shah Ebrahim and Paul Elliott and Roberto Elosua and Gudny Eiriksdottir and Michael R. Erdos and Johan Gunnar Eriksson and Maurizio F. Facheris and Stephan B. Felix and Pamela Fischer-Posovszky and Aaron R. Folsom and Nele Friedrich and Nelson B. Freimer and Mao Fu and Stefan Gaget and Pablo V. Gejman and Eco J. C. de Geus and Christian Gieger and Anette Prior Gjesing and Anuj Goel and Philippe Goyette and Harald Grallert and Juergen Graessler and Danielle M. Greenawalt and Christopher J. Groves and Vilmundur G. Gudnason and Candace Guiducci and A-L. Hartikainen and Neelam Hassanali and Alistair S. Hall and Aki Samuli Havulinna and Caroline Hayward and Andrew C. Heath and Christian Hengstenberg and Andrew A. Hicks and Anke Hinney and Albert Hofman and Georg Homuth and Jennie Hui and Wilmar Igl and Carlos Iribarren and Bo Isomaa and Kevin B. Jacobs and Ivonne Jarick and Elizabeth S. Jewell and Ulrich John and Torben J{\o}rgensen and Pekka Jousilahti and Antti M Jula and Marika A Kaakinen and Eero Kajantie and Lee M. Kaplan and Sekar Kathiresan and Johannes Kettunen and Leena Kinnunen and Joshua W. Knowles and Ivana Kol{\vc}i{\'c} and Inke R. Koenig and Seppo Koskinen and Peter Kovacs and Johanna Kuusisto and Peter Kraft and Kirsti Kval{\o}y and Jaana Laitinen and Olivier Lantieri and Chiara Lanzani and Lenore J. Launer and Cecile Lecoeur and Terho Lehtimaeki and Guillaume Lettre and Jianjun Liu and Marja-Liisa Lokki and Mattias Lorentzon and Robert N. Luben and Barbara Ludwig and Paolo Manunta and Diana Marek and Michel Marre and Nicholas G. Martin and Wendy L McArdle and Anne McCarthy and Barbara McKnight and Thomas Meitinger and Olle Melander and David Meyre and Kristian Midthjell and Grant W. Montgomery and Mario A. Morken and Andrew P. Morris and Rosanda Muli{\'c} and Julius S Ngwa and Mari Nelis and Matt J. Neville and Dale R. Nyholt and Christopher J. O’Donnell and Stephen O’Rahilly and Ken K. Ong and Ben A. Oostra and Guillaume Par{\'e} and Alex N. Parker and Markus Perola and Irene Pichler and Kirsi H. Pietilaeinen and Carl G. P. Platou and Ozren Pola{\vs}ek and Anneli Pouta and Suzanne Rafelt and Olli T. Raitakari and Nigel William Rayner and Martin Ridderstr{\aa}le and Winfried Rief and Aimo O Ruokonen and Neil R. Robertson and Peter Rzehak and Veikko V Salomaa and Alan R. Sanders and Manjinder S. Sandhu and Serena Sanna and Jouko Saramies and Markku J. Savolainen and Susann Scherag and Sabine Schipf and Stefan Schreiber and Heribert Schunkert and Kaisa Silander and Juha P. Sinisalo and David S Siscovick and Jan H Smit and Nicole Soranzo and Ulla Sovio and Jonathan C. Stephens and Ida Surakka and Amy J. Swift and Mari-Liis Tammesoo and Jean-Claude Tardif and Maris Teder-Laving and Tanya M. Teslovich and John R. Thompson and Brian Thomson and Anke Toenjes and Tiinamaija Tuomi and Joyce BJ van Meurs and Gert-Jan B. van Ommen and Vincent Vatin and Jorma Sa Viikari and Sophie Visvikis-Siest and Veronique Vitart and Carla Ivane Ganz Vogel and Benjamin F. Voight and Lindsay L. Waite and Henri Wallaschofski and G. Bragi Walters and Elisabeth Wid{\'e}n and Susanna Wiegand and Sarah H. Wild and Gonneke Willemsen and Daniel R. Witte and Jacqueline C. M. Witteman and Jianfeng Xu and Qunyuan Zhang and Lina Zgaga and Andreas Ziegler and Paavo J. Zitting and John P. Beilby and I. Sadaf Farooqi and Johannes Hebebrand and Heikki Veli Huikuri and Alan L James and Mika Kaehoenen and Douglas F. Levinson and Fabio Macciardi and Markku S Nieminen and Claes Ohlsson and Lyle J. Palmer and Paul M. Ridker and Michael Stumvoll and Jacques S. Beckmann and Heiner Boeing and Eric Boerwinkle and Dorret I. Boomsma and Mark J. Caulfield and Stephen J. Chanock and Francis S. Collins and L. Adrienne Cupples and George Davey Smith and Jeanette Erdmann and Philippe Froguel and Henrik Greonberg and Ulf Gyllensten and Per Hall and Torben Hansen and Tamara B. Harris and Andrew T. Hattersley and Richard B. Hayes and Joachim Heinrich and Frank B. Hu and Kristian Hveem and Thomas Illig and Marjo-Riitta J{\"a}rvelin and Jaakko A. Kaprio and Fredrik Karpe and Kay-Tee Khaw and Lambertus A.L.M. Kiemeney and Heiko Krude and Markku Laakso and Deborah A. Lawlor and Andres Metspalu and Patricia B. Munroe and Willem Hendrik Ouwehand and Oluf Pedersen and Brenda W.J.H. Penninx and Annette Peters and Peter P. Pramstaller and Thomas Quertermous and Thomas Reinehr and Aila M. Rissanen and Igor Rudan and Nilesh J. Samani and Peter E H Schwarz and Alan R. Shuldiner and Tim D. Spector and Jaakko Tuomilehto and Manuela Uda and Andr{\'e} G. Uitterlinden and Timo T. Valle and Martin Wabitsch and G{\'e}rard Waeber and Nicholas J. Wareham and Hugh C. Watkins and James F. Wilson and Alan F. Wright and M. Carola Zillikens and Nilanjan Chatterjee and Steven Mccarroll and Shaun M Purcell and Eric E. Schadt and Peter M. Visscher and Themistocles L. Assimes and Ingrid B. Borecki and Panos Deloukas and Caroline S Fox and Leif C. Groop and Talin Haritunians and David J. Hunter and Robert C. Kaplan and Karen L. Mohlke and Jeffrey R. O’Connell and Leena Peltonen and David Schlessinger and David P. Strachan and Cornelia van Duijn and Heinz-Erich Wichmann and Timothy M. Frayling and Unnur Thorsteinsd{\'o}ttir and Gonçalo R. Abecasis and In{\^e}s Barroso and Michael Boehnke and K{\'a}ri Stef{\'a}nsson and Kari E. North and Mark I. McCarthy and Joel N. Hirschhorn and Erik Ingelsson and Ruth J. F. Loos},
Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain largely elusive. To identify genetic loci for obesity susceptibility, we examined associations between body mass index and approximately 2.8 million SNPs in up to 123,865 individuals with targeted follow up of 42 SNPs in up to 125,931 additional individuals. We confirmed 14 known obesity susceptibility loci and identified 18 new loci associated with body mass index (P < 5 x 10(-)(8)), one of which… 

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