Association analyses based on false discovery rate implicate new loci for coronary artery disease

@article{Nelson2017AssociationAB,
  title={Association analyses based on false discovery rate implicate new loci for coronary artery disease},
  author={Christopher A. P. Nelson and Anuj Goel and Adam S. Butterworth and Stavroula Kanoni and Tom R Webb and Eirini Marouli and Lingyao Zeng and Ioanna Ntalla and Florence Y.L. Lai and Jemma C Hopewell and Olga Giannakopoulou and Tao Jiang and Stephen E. Hamby and Emanuele di Angelantonio and Themistocles L. Assimes and Erwin P. Bottinger and John Campbell Chambers and Robert J. Clarke and Colin Neil Alexander Palmer and Richard M Cubbon and Patrick T Ellinor and Raili Ermel and Evangelos Evangelou and Paul W Franks and Christopher R. Grace and Dongfeng Gu and Aroon D Hingorani and Joanna M M Howson and Erik Ingelsson and Adnan Kastrati and Thomas M. Kessler and Theodosios Kyriakou and Terho Lehtim{\"a}ki and Xiangfeng Lu and Yingchang Lu and Winfried Maerz and Ruth Mcpherson and Andres Metspalu and Mar Pujades-Rodriguez and Arno Ruusalepp and Eric E. Schadt and Amand F Schmidt and Michael J Sweeting and Pierre A. Zalloua and Kamal Alghalayini and Bernard D Keavney and Jaspal Singh Kooner and Ruth J. F. Loos and Riyaz S. Patel and Martin K. Rutter and Maciej Tomaszewski and Ioanna Tzoulaki and Eleftheria Zeggini and Jeanette Erdmann and George VZ Dedoussis and Johan L. M. Bj{\"o}rkegren and Heribert Schunkert and Martin Farrall and John Danesh and Nilesh J. Samani and H. V. Watkins and Panagiotis Deloukas},
  journal={Nature Genetics},
  year={2017},
  volume={49},
  pages={1385-1391}
}
Genome-wide association studies (GWAS) in coronary artery disease (CAD) had identified 66 loci at 'genome-wide significance' (P < 5 × 10−8) at the time of this analysis, but a much larger number of putative loci at a false discovery rate (FDR) of 5% (refs. 1,2,3,4). Here we leverage an interim release of UK Biobank (UKBB) data to evaluate the validity of the FDR approach. We tested a CAD phenotype inclusive of angina (SOFT; ncases = 10,801) as well as a stricter definition without angina (HARD… CONTINUE READING
BETA

Similar Papers

Citations

Publications citing this paper.
SHOWING 1-10 OF 52 CITATIONS, ESTIMATED 66% COVERAGE

On Zebrafish Disease Models and Matters of the Heart

VIEW 11 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Macrophage Trafficking, Inflammatory Resolution, and Genomics in Atherosclerosis: JACC Macrophage in CVD Series (Part 2).

  • Journal of the American College of Cardiology
  • 2018
VIEW 4 EXCERPTS
CITES BACKGROUND & METHODS
HIGHLY INFLUENCED

Hypertension genomics and cardiovascular prevention.

  • Annals of translational medicine
  • 2018
VIEW 5 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

FILTER CITATIONS BY YEAR

2017
2019

CITATION STATISTICS

  • 11 Highly Influenced Citations

  • Averaged 17 Citations per year from 2017 through 2019

References

Publications referenced by this paper.
SHOWING 1-10 OF 34 REFERENCES

A comprehensive 1000 Genomes–based genome-wide association meta-analysis of coronary artery disease

M Nikpay
  • Nat. Genet
  • 2015