Association among clinical response, hippocampal volume, and FKBP5 gene expression in individuals with posttraumatic stress disorder receiving cognitive behavioral therapy.

@article{LevyGigi2013AssociationAC,
  title={Association among clinical response, hippocampal volume, and FKBP5 gene expression in individuals with posttraumatic stress disorder receiving cognitive behavioral therapy.},
  author={Einat Levy-Gigi and Csilla I. Szabo and Oguz Kelemen and Szabolcs K{\'e}ri},
  journal={Biological psychiatry},
  year={2013},
  volume={74 11},
  pages={793-800}
}
BACKGROUND Posttraumatic stress disorder (PTSD) is characterized by a reduced expression of FKBP5, a key modulator of the glucocorticoid receptor. Smaller hippocampal volume has also been documented in PTSD. We explored possible changes in FKBP5 gene expression and brain structure in patients with PTSD after cognitive behavioral therapy (CBT). METHODS We measured peripheral FKBP5 RNA and volumes of the hippocampus, amygdala, and medial orbitofrontal cortex in 39 patients with PTSD before and… CONTINUE READING
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