Association Study of the Interleukin-1beta (C-511T) Genetic Polymorphism with Major Depressive Disorder, Associated Symptomatology, and Antidepressant Response

@article{Yu2003AssociationSO,
  title={Association Study of the Interleukin-1beta (C-511T) Genetic Polymorphism with Major Depressive Disorder, Associated Symptomatology, and Antidepressant Response},
  author={Younger W-Y Yu and Tai-Jui Chen and C N Hong and Hung-Mei Chen and Shih-Jen Tsai},
  journal={Neuropsychopharmacology},
  year={2003},
  volume={28},
  pages={1182-1185}
}
Proinflammatory cytokines, including interleukin (IL)-1beta, are suggested to have a role in the pathogenesis of major depressive disorder (MDD) and be related to the therapeutic effects of antidepressants. To elucidate a genetic predisposition of MDD, we studied biallelic polymorphism in the promoter region (position -511) of the IL-1beta gene in 157 patients with MDD and in 112 controls. We also examined the association of this polymorphism and fluoxetine therapeutic response in 119 MDD… CONTINUE READING

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