Association Study of G Protein‐Coupled Receptor Kinase 4 Gene Variants with Essential Hypertension in Northern Han Chinese

@article{Wang2006AssociationSO,
  title={Association Study of G Protein‐Coupled Receptor Kinase 4 Gene Variants with Essential Hypertension in Northern Han Chinese},
  author={Yaping Wang and Biao Li and Wei-yan Zhao and Pei Liu and Qi Zhao and Shufeng Chen and Hongfan Li and Dongfeng Gu},
  journal={Annals of Human Genetics},
  year={2006},
  volume={70}
}
To investigate the association between polymorphisms in the G protein‐coupled receptor kinase 4 gene (GRK4) (R65L, A142V and A486V) and essential hypertension in northern Han Chinese, we conducted a case‐control study consisting of 503 individuals with essential hypertension (HT) and 490 age‐, gender‐, and area‐matched normotensive (NT) controls. The three GRK4 variants were genotyped by PCR‐RFLP analysis. Both haplotype and single locus analysis were used to process the genotyping data. The… 
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