Association Of Plasma And Urinary Mutant DNA With Clinical Outcomes In Muscle Invasive Bladder Cancer

  title={Association Of Plasma And Urinary Mutant DNA With Clinical Outcomes In Muscle Invasive Bladder Cancer},
  author={Keval M Patel and Kristan E van der Vos and Christopher G. Smith and Florent Mouliere and Dana Wai Yi Tsui and James M. Morris and Dineika Chandrananda and F Marass and Daan A. van den Broek and David E. Neal and Vincent J Gnanapragasam and Tim Forshew and Bas Wilhelmus Gerardus van Rhijn and Charlie E Massie and Nitzan Rosenfeld and Michiel S. van der Heijden},
  booktitle={Scientific Reports},
Muscle Invasive Bladder Cancer (MIBC) has a poor prognosis. Whilst patients can achieve a 6% improvement in overall survival with Neo-Adjuvant Chemotherapy (NAC), many do not respond. Body fluid mutant DNA (mutDNA) may allow non-invasive identification of treatment failure. We collected 248 liquid biopsy samples including plasma, cell pellet (UCP) and supernatant (USN) from spun urine, from 17 patients undergoing NAC. We assessed single nucleotide variants and copy number alterations in mutDNA… CONTINUE READING
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