Association Between the Various Mutations in Viral Core Promoter Region to Different Stages of Hepatitis B, Ranging of Asymptomatic Carrier State to Hepatocellular Carcinoma

@article{Yin2011AssociationBT,
  title={Association Between the Various Mutations in Viral Core Promoter Region to Different Stages of Hepatitis B, Ranging of Asymptomatic Carrier State to Hepatocellular Carcinoma},
  author={Jianhua Yin and J. Xie and S. Liu and Hongwei Zhang and Lei Han and Wen-ying Lu and Qiuxia Shen and Guozhang Xu and H. Dong and Jie Shen and J. Zhang and Jiankang Han and L. Wang and Y. Liu and F. Wang and Jun Zhao and Q. Zhang and Wu Ni and Hongyang Wang and G. Cao},
  journal={The American Journal of Gastroenterology},
  year={2011},
  volume={106},
  pages={81-92}
}
OBJECTIVES:The objective of this study was to determine the association of 19 mutations with frequencies ≥10% in the core promoter region of hepatitis B virus (HBV) with chronic hepatitis B (CHB), liver cirrhosis, and hepatocellular carcinoma (HCC).METHODS:Eight hundred forty-six asymptomatic hepatitis B surface antigen carriers (ASCs), 235 CHB patients, 188 cirrhosis patients, and 190 HCC patients with intact data of HBV genotyping, DNA sequencing, and serological parameters were studied… Expand
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