Association Between the Various Mutations in Viral Core Promoter Region to Different Stages of Hepatitis B, Ranging of Asymptomatic Carrier State to Hepatocellular Carcinoma

  title={Association Between the Various Mutations in Viral Core Promoter Region to Different Stages of Hepatitis B, Ranging of Asymptomatic Carrier State to Hepatocellular Carcinoma},
  author={Jianhua Yin and Jiaxin Xie and Shijian Liu and Hongwei Zhang and Lei Han and Wen-ying Lu and Qiuxia Shen and Guozhang Xu and Hong-jun Dong and Jie Shen and Jun Zhang and Jiankang Han and Lin Wang and Yan Liu and Fan Wang and Jun Zhao and Qian Zhang and Wu Ni and Hongyang Wang and Guangwen Cao},
  journal={The American Journal of Gastroenterology},
OBJECTIVES:The objective of this study was to determine the association of 19 mutations with frequencies ≥10% in the core promoter region of hepatitis B virus (HBV) with chronic hepatitis B (CHB), liver cirrhosis, and hepatocellular carcinoma (HCC).METHODS:Eight hundred forty-six asymptomatic hepatitis B surface antigen carriers (ASCs), 235 CHB patients, 188 cirrhosis patients, and 190 HCC patients with intact data of HBV genotyping, DNA sequencing, and serological parameters were studied… 

Hepatitis B virus subgenotype C2- and B2-associated mutation patterns may be responsible for liver cirrhosis and hepatocellular carcinoma, respectively

  • Y. ChenS. WuC. QiuD. YuX. Wang
  • Biology
    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas
  • 2013
Multivariate regression analyses showed that HBV subgenotype C2 and C2-associated mutation patterns were independent risk factors for LC when CHB was the control, and that B2- associated mutation patterns (C1810T, A1846T, G1862T, and G1896A) were independently associated with HCC compared with LC.

Frequency and clinical significance of core promoter and precore region mutations in Tunisian patients infected chronically with hepatitis B

It was shown that substitutions at nucleotides 1762, 1764 and 1899 have an impact on the disease progression of chronic hepatitis B virus and it was the first report for specific mutations in the URS region for genotype D.

Novel Point and Combo-Mutations in the Genome of Hepatitis B Virus-Genotype D: Characterization and Impact on Liver Disease Progression to Hepatocellular Carcinoma

A distinct pattern of mutations distributed across the entire HBV genome may be useful in predicting HCC in high-risk CHB patients and pattern of mutational combinations may exert greater impact on HCC risk prediction more accurately than point mutations.

Novel X gene point mutations in chronic hepatitis B and HBV related cirrhotic patients.

Mutations within enhancer II and BCP regions of hepatitis B virus in relation to advanced liver diseases in patients infected with subgenotype B3 in Indonesia

Multivariate analysis showed that, in patients older than 45 years, C1638T and T1753V mutations constituted independent risk factors for the advancement of liver diseases, and may serve as predictive markers for the progression of liver disease in Indonesia and other countries, where subgenotype B3 infection is prevalent.

Hepatitis B Virus Combo Mutations Improve the Prediction and Active Prophylaxis of Hepatocellular Carcinoma: A Clinic-Based Cohort Study

To prevent HCC, patients infected with HBV carrying A1762T/G1764A or C1653T, but not T1753V, should be given priority of receiving antiviral treatments.

The Characteristic Changes in Hepatitis B Virus X Region for Hepatocellular Carcinoma: A Comprehensive Analysis Based on Global Data

Mutations associated with HCC risk were mainly located in HBx transactivation domain, viral promoter, protein/miRNA binding sites, and the area for immune epitopes, suggesting molecular counteractions between the virus and host during hepatocarcinogenesis.

Review on hepatitis B virus precore/core promoter mutations and their correlation with genotypes and liver disease severity

Thorough perception and knowledge of HBV genetic variety and mutants could be vital to discover techniques for the prognosis and control ofHBV infection.

Mutational complex genotype of the hepatitis B virus X /precore regions as a novel predictive marker for hepatocellular carcinoma

MCG in the HBV X/precore regions is a risk indicator for HCC, and might serve as a new guide to the HCC screening scheme for chronic HBV carriers.

Association between HBV Pre-S mutations and the intracellular HBV DNAs in HBsAg-positive hepatocellular carcinoma in China

This study aimed to determine the clinical features and the contribution of HBV mutations to postoperative prognosis for hepatocellular carcinoma patients with HBsAg (+) in China and to disclose the virological features to implement a more clinically personalized therapy and to improve the prognosis of HCC patients.



Clinical Significance of Hepatitis B Virus (HBV) Genotypes and Precore and Core Promoter Mutations Affecting HBV e Antigen Expression in Taiwan

It is suggested that pathogenic differences between HBeAg-positive and -negative patients may exist and HBV genotype C and the T1762 and A1764 mutations may play a role in HBV-related liver cirrhosis, and these could serve as molecular markers for prediction of the clinical outcomes of chronic HBV patients.

Basal core promoter mutations of hepatitis B virus increase the risk of hepatocellular carcinoma in hepatitis B carriers.

It is suggested that HBV carriers with T1762/A1764 basal core promoter mutant are at increased risk for HCC and that this mutant may contribute to the pathogenesis of HBV infection.

Specific mutations in the enhancer II/core promoter/precore regions of hepatitis B virus subgenotype C2 in Korean patients with hepatocellular carcinoma

The presence of the T1653, A1689, and/or T1762/A1764 mutations were associated with the development of HCC in Korean patients infected with HBV/C2 and no association was observed between mutations in the precore region and HCC.

Associations Between Hepatitis B Virus Genotype and Mutants and the Risk of Hepatocellular Carcinoma

HBV genotype C and specific alleles of BCP and precore were associated with risk of HCC, and these associations were independent of serum HBV DNA level.

Role of hepatitis B virus genotypes Ba and C, core promoter and precore mutations on hepatocellular carcinoma: a case control study.

There was a significantly higher prevalence of both genotype C and CP mutations in patients with HCC, and the association between HBV genotypes C and HCC was probably not genuine but was due to the high percentage of CP mutationsIn patients with genotypeC.

Role of hepatitis B virus genotype mixture, subgenotypes C2 and B2 on hepatocellular carcinoma: compared with chronic hepatitis B and asymptomatic carrier state in the same area.

HBV coinfections with two or three genotypes were associated with higher viral load and more severe course of the disease and HBV B2 infection was related to HCC recurrence.

Pre-S deletion and complex mutations of hepatitis B virus related to advanced liver disease in HBeAg-negative patients.

It is indicated that pre-S deletion and combined mutations of HBV are useful molecular markers for predicting the clinical outcomes of HBeAg-negative patients.

Risk for hepatocellular carcinoma with respect to hepatitis B virus genotypes B/C, specific mutations of enhancer II/core promoter/precore regions and HBV DNA levels

The risks for hepatocellular carcinoma (HCC) with respect to hepatitis B virus genotypes, specific viral mutations (MT), serum HBV DNA levels, and cirrhosis are examined, showing that CP-MT, T1653, HBVDNA levels ⩾4 log10 copies/ml and cir rhosis are independent factors for development of HCC.

X gene mutations in hepatitis B patients with cirrhosis, with and without hepatocellular carcinoma

B1499 is a novel mutation associated with HCC in Korean patients with cirrhosis infected with HBV genotype C2, and patients in the B1499 mutation group exhibited significantly higher AST and ALT levels compared with patients infected with the wild‐type virus.