Association Between the Interferon Gamma 874 T/A Polymorphism and the Severity of Valvular Damage in Patients with Rheumatic Heart Disease

@article{Teker2017AssociationBT,
  title={Association Between the Interferon Gamma 874 T/A Polymorphism and the Severity of Valvular Damage in Patients with Rheumatic Heart Disease},
  author={Erhan Teker and A. Başak Akadam-Teker and Oguz Ozturk and Allison Pinar Eronat and Kivanç Yalin and Sukriye Ebru Golcuk and Zehra Bugra},
  journal={Biochemical Genetics},
  year={2017},
  volume={56},
  pages={225-234}
}
AbstractInterferon gamma (IFN-γ) is a multifunctional cytokine that plays an important role in modulating almost all phases of the immune response and may be responsible for the increased valvular fibrosis and calcification in the pathogenesis of rheumatic heart disease (RHD). The aim of this study was to investigate the possible relationship between the IFN-γ +874 T/A polymorphism and the severity of valvular damage in the Turkish population. The IFN-γ genotypes were determined in 152 RHD… CONTINUE READING
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