Association Between Polymorphisms in the Dopamine Transporter Gene and Depression

@article{Haeffel2008AssociationBP,
  title={Association Between Polymorphisms in the Dopamine Transporter Gene and Depression},
  author={Gerald J Haeffel and Marya Getchell and R. Koposov and C. Yrigollen and Colin G. De Young and B. Klinteberg and L. Oreland and V. Ruchkin and E. Grigorenko},
  journal={Psychological Science},
  year={2008},
  volume={19},
  pages={62 - 69}
}
Previous research has generated examples of how genetic and environmental factors can interact to create risk for psychopathology. Using a gene-by-environment (G X E) interaction design, we tested whether three polymorphisms in the dopamine transporter gene (DAT1, also referred to as SLC6A3, located at 5p15.33) interacted with maternal parenting style to predict first-onset episodes of depression. Participants were male adolescents (N = 176) recruited from a juvenile detention center in… Expand
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THE EFFECT OF PARENTAL INFLUENCE AND THE DOPAMINE TRANSPORTER (DAT1) GENE ON EARLY ANTISOCIAL BEHAVIOR IN CHILDREN: DETERMINING RISK FOR DELINQUENCY USING A GxE
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Maternal drug use, punishment of the child, and child’s lack of attachment to mother were all significantly related to increased delinquency. Expand
Association of promoter variants of human dopamine transporter gene with schizophrenia in Han Chinese
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The promoter region of the DAT1 gene may play a role in increasing susceptibility to schizophrenia, but does not affect the severity of psychotic symptoms in Han Chinese. Expand
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