Association Between Polymorphisms in the Dopamine Transporter Gene and Depression

@article{Haeffel2008AssociationBP,
  title={Association Between Polymorphisms in the Dopamine Transporter Gene and Depression},
  author={Gerald J. Haeffel and Marya Getchell and Roman A Koposov and Carolyn M Yrigollen and Colin G. De Young and Britt af Klinteberg and Lars Oreland and Vladislav Ruchkin and Elena L. Grigorenko},
  journal={Psychological Science},
  year={2008},
  volume={19},
  pages={62 - 69}
}
Previous research has generated examples of how genetic and environmental factors can interact to create risk for psychopathology. Using a gene-by-environment (G X E) interaction design, we tested whether three polymorphisms in the dopamine transporter gene (DAT1, also referred to as SLC6A3, located at 5p15.33) interacted with maternal parenting style to predict first-onset episodes of depression. Participants were male adolescents (N = 176) recruited from a juvenile detention center in… 

Figures and Tables from this paper

The Catechol-O-Methyltransferase and Dopamine Transporter Genes Moderated the Impact of Peer Relationships on Adolescent Depressive Symptoms: A Gene–Gene–Environment Study
TLDR
This study underscores complex polygenic underpinnings of depression and lends support for the gene–gene–environment interactions implicated in the etiology of depressive symptoms.
Gene–environment interactions: early life stress and risk for depressive and anxiety disorders
TLDR
Overall, there is support for GxE effects of ELS on the risk for depressive and anxiety outcomes, and future studies of E LS in this context will require careful attention to methodologic considerations.
Genetically determined dopamine availability predicts disposition for depression
TLDR
The present findings indicate that gene variations of the DA system previously associated with PEM are at the same time protective against high NEM and can therefore constitute a resilience factor against depression.
Association of C/T polymorphism in intron 14 of the dopamine transporter gene (rs40184) with major depression in a northeastern Thai population.
TLDR
It is concluded that there is a tendency towards an association between the homozygous TT genotype of the rs40184 single nucleotide polymorphism and an increased risk for MDD in this northeastern Thai population.
Trajectories of depressive symptoms, dopamine D2 and D4 receptors, family socioeconomic status and social support in adolescence and young adulthood
Objectives The purpose of this study is two-fold. First, we tested the association between dopamine D2 and D4 receptors and a trajectory of depressive symptoms in adolescence and young adulthood.
THE EFFECT OF PARENTAL INFLUENCE AND THE DOPAMINE TRANSPORTER (DAT1) GENE ON EARLY ANTISOCIAL BEHAVIOR IN CHILDREN: DETERMINING RISK FOR DELINQUENCY USING A GxE
TLDR
Maternal drug use, punishment of the child, and child’s lack of attachment to mother were all significantly related to increased delinquency.
...
...

References

SHOWING 1-10 OF 50 REFERENCES
Family-based association studies of bipolar disorder with candidate genes involved in dopamine neurotransmission: DBH, DAT1, COMT, DRD2, DRD3 and DRD5
TLDR
Family-based association studies for polymorphisms at three genes involved in the metabolism of dopamine, dopamine transporter, dopamine-β-hydroxylase and catechol-O-methyl transferase and three dopamine receptors are conducted.
Association of attention-deficit disorder and the dopamine transporter gene.
Attention-deficit hyperactivity disorder (ADHD) has been shown to be familial and heritable, in previous studies. As with most psychiatric disorders, examination of pedigrees has not revealed a
Association of unipolar major depressive disorder with genes of the serotonergic and dopaminergic pathways
TLDR
This study does not support a major role for these polymorphisms in contributing to susceptibility to MDD, although it does not preclude minor effects.
Family-based study of markers at the 5′-flanking region of the human dopamine transporter gene reveals potential association with schizophrenic psychoses
TLDR
The genetic involvement of distinct hSLC6A3 genotypes in schizophrenia is supported and replication in extended samples is proposed and examination of the functional relevance of the associated genotypes on human dopamine transporter expression is proposed.
A dopamine transporter gene functional variant associated with cocaine abuse in a Brazilian sample.
TLDR
A robust association between cocaine dependence and a VNTR allele in SLC6A3 is demonstrated, conferring a small but detectable effect, and it is shown that this VN TR may be functional.
Measured Gene-Environment Interactions in Psychopathology
  • T. Moffitt, A. Caspi, M. Rutter
  • Psychology
    Perspectives on psychological science : a journal of the Association for Psychological Science
  • 2006
TLDR
It is suggested that information about nurture might be harnessed to make new discoveries about the nature of psychopathology and the potential benefits of studying measured gene-environment interactions for basic neuroscience, gene hunting, intervention, and public understanding of genetics.
Platelet MAO-B, personality, and psychopathology.
TLDR
It was hypothesized that low platelet MAO-B activity does not directly predispose individuals to psychopathology but is related to specific personality traits, which in turn represent a vulnerability factor for psychopathology.
Low activity allele of catechol‐o‐methyltransferase gene and Japanese unipolar depression
TLDR
The results suggest the COMTL allele contributed to the etiologies of depressive disorders.
Involvement of serotonin and dopamine in the mechanism of action of novel antidepressant drugs: a review.
TLDR
Analysis of the current literature indicates that long-term treatment with antidepressants causes adaptive changes of the serotonergic and dopaminergic systems, and this article reports studies reporting the biochemical, behavioral, and clinical effects of tricyclic antidepressants, monoamine oxidase inhibitors, selective serotonin reuptake inhibitors, and antagonists of serotonin-2 receptors.
...
...