Association Between Polymorphisms in the Dopamine Transporter Gene and Depression

@article{Haeffel2008AssociationBP,
  title={Association Between Polymorphisms in the Dopamine Transporter Gene and Depression},
  author={Gerald J Haeffel and Marya Getchell and Roman A. Koposov and Carolyn M. Yrigollen and Colin G. De Young and Britt af Klinteberg and Lars Oreland and Vladislav Ruchkin and Elena L. Grigorenko},
  journal={Psychological Science},
  year={2008},
  volume={19},
  pages={62 - 69}
}
Previous research has generated examples of how genetic and environmental factors can interact to create risk for psychopathology. Using a gene-by-environment (G X E) interaction design, we tested whether three polymorphisms in the dopamine transporter gene (DAT1, also referred to as SLC6A3, located at 5p15.33) interacted with maternal parenting style to predict first-onset episodes of depression. Participants were male adolescents (N = 176) recruited from a juvenile detention center in… Expand
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TLDR
It is concluded that there is a tendency towards an association between the homozygous TT genotype of the rs40184 single nucleotide polymorphism and an increased risk for MDD in this northeastern Thai population. Expand
Dopamine transporter 1 (DAT1) rs40184 single nucleotide polymorphism is not associated with the Malaysian major depressive disorder subjects
TLDR
No significant association was obtained between DAT1 and MDD in the Malaysian population and Hardy Weinberg equilibrium for the distribution of alleles and genotypes was tested. Expand
Trajectories of depressive symptoms, dopamine D2 and D4 receptors, family socioeconomic status and social support in adolescence and young adulthood
Objectives The purpose of this study is two-fold. First, we tested the association between dopamine D2 and D4 receptors and a trajectory of depressive symptoms in adolescence and young adulthood.… Expand
THE EFFECT OF PARENTAL INFLUENCE AND THE DOPAMINE TRANSPORTER (DAT1) GENE ON EARLY ANTISOCIAL BEHAVIOR IN CHILDREN: DETERMINING RISK FOR DELINQUENCY USING A GxE
TLDR
Maternal drug use, punishment of the child, and child’s lack of attachment to mother were all significantly related to increased delinquency. Expand
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