Association Between MTHFR C677T Polymorphism and Methotrexate Treatment Outcome in Rheumatoid Arthritis Patients: A Systematic Review and Meta-Analysis.

@article{Shao2017AssociationBM,
  title={Association Between MTHFR C677T Polymorphism and Methotrexate Treatment Outcome in Rheumatoid Arthritis Patients: A Systematic Review and Meta-Analysis.},
  author={W. Shao and Yi Yuan and Y. Li},
  journal={Genetic testing and molecular biomarkers},
  year={2017},
  volume={21 5},
  pages={
          275-285
        }
}
  • W. Shao, Yi Yuan, Y. Li
  • Published 2017
  • Medicine
  • Genetic testing and molecular biomarkers
  • PURPOSE Methotrexate (MTX) is one of the most widely used disease-modifying antirheumatic drugs for the treatment of rheumatoid arthritis (RA). However, its efficacy in RA patients is variable and unpredictable. Methylene tetrahydrofolate reductase (MTHFR) is an important enzyme in the MTX pathway and is involved in folate metabolism and DNA synthesis. Several studies have examined the association between the MTHFR C677T polymorphism and MTX toxicity and efficacy in RA, but their conclusions… CONTINUE READING
    Genetic markers in methotrexate treatments
    • 7

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 67 REFERENCES
    Metaanalysis of Methylenetetrahydrofolate Reductase (MTHFR) Polymorphisms Affecting Methotrexate Toxicity
    • 103
    • Highly Influential
    • Open Access
    MTHFR gene polymorphisms and outcome of methotrexate treatment in patients with rheumatoid arthritis: analysis of key polymorphisms and meta-analysis of C677T and A1298C polymorphisms
    • 74
    • Highly Influential
    • Open Access
    Association of the MTHFR C677T and A1298C polymorphisms with methotrexate toxicity in rheumatoid arthritis: a meta-analysis
    • 36
    • Highly Influential