Association Between IL-10 Gene Promoter Polymorphism and Hepatitis B Viral Infection in an Egyptian Population

@article{Talaat2014AssociationBI,
  title={Association Between IL-10 Gene Promoter Polymorphism and Hepatitis B Viral Infection in an Egyptian Population},
  author={Roba M Talaat and Mahmoud Fathy Dondeti and Soha Z. El-Shenawy and Omaima A. Khamiss},
  journal={Biochemical Genetics},
  year={2014},
  volume={52},
  pages={387-402}
}
Cytokines play critical roles in the pathogenesis of hepatitis B virus infection (HBV). This work was designed to study the effect of IL-10 gene polymorphisms (−1082G/A and −819C/T) on susceptibility of Egyptians to HBV. Genotyping was performed using single-stranded polymorphism-polymerase chain reaction in 118 Egyptian hepatitis B patients and 119 healthy controls, and IL-10 serum levels were measured using ELISA. The frequency of IL-10 −1082G/G was significantly higher in HBV patients than… CONTINUE READING