Association Between Hemoglobin Glycation Index and Risk of Cardiovascular Disease and All Cause Mortality in Type 2 Diabetic Patients: A Meta-Analysis

@article{Wu2021AssociationBH,
  title={Association Between Hemoglobin Glycation Index and Risk of Cardiovascular Disease and All Cause Mortality in Type 2 Diabetic Patients: A Meta-Analysis},
  author={Jian-di Wu and Dong-liang Liang and Yue Xie and Meifang Chen and Hai-hong Chen and Dan Sun and Hui-qi Hu},
  journal={Frontiers in Cardiovascular Medicine},
  year={2021},
  volume={8}
}
Background: The hemoglobin glycation index (HGI) has been proposed as a marker to quantify inter-individual variation in hemoglobin glycosylation. However, whether HGI is associated with an increased risk of diabetic complications independent of glycated hemoglobin (HbA1c) remains unclear. This meta-analysis aimed to determine the association between HGI and the risk of all cause mortality and composite cardiovascular disease (CVD). Methods: PubMed, and EMBASE databases were searched for… 
1 Citations

Figures and Tables from this paper

References

SHOWING 1-10 OF 53 REFERENCES

Relationship between hemoglobin glycation index and extent of coronary heart disease in individuals with type 2 diabetes mellitus: a cross-sectional study

TLDR
HGI correlated with the extent of CHD in individuals with T2D and enables cardiovascular risk stratification in at risk individuals, and provides useful information concerning cardiovascular risk in clinical practice.

Association of hemoglobin glycation index with outcomes of acute ischemic stroke in type 2 diabetic patients

TLDR
A U-shaped association between HGI and the prognosis of diabetic patients with ischemic stroke was found, with low HGI associated with an increased risk of poor prognosis, compared with moderate HGI.

Hemoglobin Glycation Index Is Associated With Cardiovascular Diseases in People With Impaired Glucose Metabolism

TLDR
High HGI was independently associated with overall and individual CVDs, suggesting that discrepancy between HbA1c and fasting glucose levels can reflect vascular health in subjects with impaired glucose metabolism.

The haemoglobin glycation index as predictor of diabetes-related complications in the AleCardio trial

TLDR
HGI predicts mortality in diabetes patients with acute coronary syndromes, but no better than HbA1c, and this difference disappeared after adjustment for duration of diabetes, insulin and sulphonylurea use.

Triglyceride glucose and haemoglobin glycation index for predicting outcomes in diabetes patients with new-onset, stable coronary artery disease: a nested case-control study

TLDR
It is indicated that TyG index might have better prognostic value than HGI in T2DM patients with new-onset, stable CAD, and both TyG and HGI were associated with increased risk of MACCEs after adjusting for confounding risk factors.

Association between hemoglobin glycation index and cardiometabolic risk factors in Korean pediatric nondiabetic population

TLDR
HGI was associated with CMRFs in a Korean pediatric population and high HGI might be an independent risk factor for CMRF clustering and ALT elevation in overweight/obese youth.

Association between hemoglobin glycation index with insulin resistance and carotid atherosclerosis in non-diabetic individuals

TLDR
The notion that HGI may be a useful tool to identify a subset of nondiabetic individuals conceivably harboring a higher risk of cardiovascular disease is supported.

Association between prediabetes and risk of cardiovascular disease and all cause mortality: systematic review and meta-analysis

TLDR
Prediabetes, defined as impaired glucose tolerance, impaired fasting glucose, or raised HbA1c, was associated with an increased risk of cardiovascular disease.
...