Association Between Cannabis and Psychosis: Epidemiologic Evidence

@article{Gage2016AssociationBC,
  title={Association Between Cannabis and Psychosis: Epidemiologic Evidence},
  author={Suzanne H. Gage and Matthew Hickman and Stanley Zammit},
  journal={Biological Psychiatry},
  year={2016},
  volume={79},
  pages={549-556}
}

Tables from this paper

Cannabis and Psychosis Through the Lens of DSM-5

  • Nathan PearsonJ. Berry
  • Psychology, Medicine
    International journal of environmental research and public health
  • 2019
This review examines cannabis/psychosis associations as they pertain to Cannabis Intoxication, Cannabis-Induced Psychotic Disorder, and Schizophrenia to allow for an understanding of the cannabis and psychosis association along something approaching a continuum.

Cannabis and Psychosis: A Review of the Risk Factors Involved

A significant inverse relationship exists between cannabidiol (CBD) and psychosis: cannabodiol is associated with less psychotic symptoms and manifests antipsychotic properties.

Are cannabis-using and non-using patients different groups? Towards understanding the neurobiology of cannabis use in psychotic disorders

A systematic review of 70 studies, including over 3000 patients with psychotic disorders or at increased risk of psychotic disorder, is undertaken in order to delineate potential neurobiological and neurochemical mechanisms that may underlie the effects of cannabis in psychotic disorders and suggest avenues for future research.

Cannabis Use and the Risk for Psychosis and Affective Disorders

The evidence that heavy use of high-THC/low-CBD types of cannabis increases the risk of psychosis is sufficiently strong to merit public health education and the possibility that CBD may be therapeutically useful.

Cannabis use and psychosis: a review of reviews

  • A. HasanR. Keller E. Hoch
  • Psychology, Medicine
    European Archives of Psychiatry and Clinical Neuroscience
  • 2019
A systematic review of meta-analyses and systematic reviews to evaluate the impact of cannabis use on the onset and course of psychoses found that cannabis use is associated with a dose-dependent risk of developing psychotic illness, and cannabis users have an earlier onset of psychotic illness compared to non-users.

Cannabis-associated psychosis: Neural substrate and clinical impact

Cannabis and psychosis: the impact of polydrug use

Compared with no drug use, the use of cannabis only did not increase the risk of psychosis while the odds ratio for cannabis and other drug were statistically significant, and cannabis use may be a proxy for other drug use in research studies.

Assessing causality in associations between cannabis use and schizophrenia risk: a two-sample Mendelian randomization study

Evidence is found that cannabis initiation increases the risk of schizophrenia, although the size of the causal estimate is small, and stronger evidence that schizophrenia risk predicts cannabis initiation, possibly as genetic instruments for schizophrenia are stronger than for cannabis initiation.

Examining pathways between genetic liability for schizophrenia and patterns of tobacco and cannabis use in adolescence

Evidence is provided that genetic risk for schizophrenia is associated with patterns of cannabis use during adolescence, and investigation of pathways other than the cognitive, emotional, and behavioral phenotypes examined here is required to identify modifiable targets to reduce the public health burden of cannabis Use in the population.

Cannabis use and risk of schizophrenia: a Mendelian randomization study

Genetic evidence adds to the substantial evidence base that has previously identified cannabis use to associate with increased risk of schizophrenia, by suggesting that the relationship is causal, to inform public health messages about cannabis use.
...

References

SHOWING 1-10 OF 97 REFERENCES

Cannabis Use and Psychosis: A Review of Clinical and Epidemiological Evidence ∗

It is still unclear whether this means that cannabis use precipitates schizophrenia, whether cannabis use is a form of ‘self-medication’, or whether the association is due to the use of other drugs, such as amphetamines, which heavy cannabis users are more likely to use.

Cannabis as a risk factor for psychosis: systematic review

The available evidence supports the hypothesis that cannabis is an independent risk factor for psychosis and the development of psychotic symptoms, particularly in vulnerable populations, and is likely to have beneficial effects on psychiatric morbidity.

Tests of causal linkages between cannabis use and psychotic symptoms.

The present study suggests that the association between cannabis use and psychotic symptoms is unlikely to be due to confounding factors; and the direction of causality is from cannabis use to psychotic symptoms.

Association of cannabis use with prodromal symptoms of psychosis in adolescence.

Cannabis use is associated with prodromal symptoms of psychosis in adolescence and a dose-response effect was seen.

Genetic predisposition to schizophrenia associated with increased use of cannabis

In a sample of 2082 healthy individuals, an association is shown between an individual’s burden of schizophrenia risk alleles and use of cannabis, suggesting that part of the association between schizophrenia and cannabis is due to a shared genetic aetiology.

Cannabis use in adolescence and risk for adult psychosis: longitudinal prospective study

This is the first prospective longitudinal study of adolescent cannabis use as a risk factor for adult schizophreniform disorder, taking into account childhood psychotic symptoms, and the Dunedin multidisciplinary health and development study has a 96% follow up rate at age 26.

Cannabis use and risk of psychotic or affective mental health outcomes: a systematic review

Cannabis use and psychosis: a longitudinal population-based study.

Results confirm previous suggestions that cannabis use increases the risk of both the incidence of psychosis in psychosis-free persons and a poor prognosis for those with an established vulnerability to psychotic disorder.
...